[HTML][HTML] SARS-CoV-2 E protein: Pathogenesis and potential therapeutic development

S Zhou, P Lv, M Li, Z Chen, H Xin, S Reilly… - Biomedicine & …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, which has seriously affected human health worldwide. The discovery of …

Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

P Chen, M Wu, Y He, B Jiang, ML He - Signal Transduction and …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …

ATG14 targets lipid droplets and acts as an autophagic receptor for syntaxin18-regulated lipid droplet turnover

Z Yuan, K Cai, J Li, R Chen, F Zhang, X Tan… - Nature …, 2024 - nature.com
Lipid droplets (LDs) are dynamic lipid storage organelles that can be degraded by
autophagy machinery to release neutral lipids, a process called lipophagy. However …

Betacoronavirus assembly: clues and perspectives for elucidating SARS-CoV-2 particle formation and egress

D Bracquemond, D Muriaux - MBio, 2021 - Am Soc Microbiol
In 2019, a new pandemic virus belonging to the betacoronavirus family emerged, severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This new coronavirus appeared in …

COVID-19 Biogenesis and Intracellular Transport

AA Mironov, MA Savin, GV Beznoussenko - International journal of …, 2023 - mdpi.com
SARS-CoV-2 is responsible for the COVID-19 pandemic. The structure of SARS-CoV-2 and
most of its proteins of have been deciphered. SARS-CoV-2 enters cells through the …

Distinct motifs in the E protein are required for SARS-CoV-2 virus particle formation and lysosomal deacidification in host cells

K Miura, Y Suzuki, K Ishida, M Arakawa, H Wu… - Journal of …, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is a major public health
concern, but the mechanisms underlying its viral particle formation are not well understood …

Bidirectional interplay between SARS-CoV-2 and autophagy

H Zhou, Z Hu, S Castro-Gonzalez - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as the causative agent of
the recent COVID-19 pandemic, continues representing one of the main health concerns …

[HTML][HTML] Super-resolution proximity labeling reveals anti-viral protein network and its structural changes against SARS-CoV-2 viral proteins

YB Lee, M Jung, J Kim, A Charles, W Christ, J Kang… - Cell reports, 2023 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells
by interacting with host factors following infection. To understand the virus and host …

The deubiquitinase USP29 promotes SARS-CoV-2 virulence by preventing proteasome degradation of ORF9b

W Gao, L Wang, X Ju, S Zhao, Z Li, M Su, J Xu, P Wang… - Mbio, 2022 - Am Soc Microbiol
Ubiquitin signaling is essential for immunity to restrict pathogen proliferation. Due to its
enormous impact on human health and the global economy, intensive efforts have been …

Membrane remodeling and trafficking piloted by SARS-CoV-2

MC Sergio, S Ricciardi, AM Guarino, L Giaquinto… - Trends in Cell …, 2024 - cell.com
The molecular mechanisms underlying SARS-CoV-2 host cell invasion and life cycle have
been studied extensively in recent years, with a primary focus on viral entry and …