Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Osteoarthritis (OA) is a common degenerative disease of the joints. It is primarily caused by
age, obesity, mechanical damage, genetics, and other factors, leading to cartilage …

Tumor-derived exosomes are emerging mediators of cancer cachexia. Clarifying the
regulation of exosome biogenesis and finding possible targets for cancer cachexia therapy …

As one of the well-known hallmarks of cancer malignancy, most proliferating cancer cells
exhibit enhanced rates of glycolysis. Hexokinase 2 (HK2) is the rate-limiting enzyme …

Glycolysis is the primary source of energy for cancer growth and metastasis. The shift in
metabolism from mitochondrial oxidative phosphorylation to aerobic glycolysis is called the …

We aimed to investigate the role of renal pericyte pyruvate kinase M2 (PKM2) in the
progression of acute kidney injury (AKI) to chronic kidney disease (CKD). The role of PKM2 …

Multiple myeloma (MM) is an incurable hematological malignancy that lacks effective
therapeutic interventions. Ferroptosis is a newly discovered form of cell death that has …

Gastric cancer (GC) remains a common cause of cancer death worldwide. Evidence has
found that butyrate exhibited antitumor effects on GC cells. However, the mechanism by …

Esophageal carcinoma is among the most fatal malignancies with increasing incidence
globally. Tumor onset and progression can be driven by metabolic reprogramming …

Cardiovascular diseases (CVDs) are the world's leading cause of death, accounting for 32%
of all fatalities. Although therapeutic agents are available for CVDs, however, most of them …