[PDF][PDF] One year in review 2020: pathogenesis of rheumatoid arthritis

D Giannini, M Antonucci, F Petrelli, S Bilia… - Clin Exp …, 2020 - clinexprheumatol.org
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by both
genetic, epigenetic and environmental factors. The discovery of new gene polymorphisms …

Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases

DM Heuberger, RA Schuepbach - Thrombosis journal, 2019 - Springer
Inflammatory diseases have become increasingly prevalent with industrialization. To
address this, numerous anti-inflammatory agents and molecular targets have been …

Interleukin-6 in rheumatoid arthritis

F Pandolfi, L Franza, V Carusi, S Altamura… - International journal of …, 2020 - mdpi.com
The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent
years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in …

NK cells in autoimmune diseases: protective or pathogenic?

M Liu, S Liang, C Zhang - Frontiers in Immunology, 2021 - frontiersin.org
Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

Natural products for the treatment of autoimmune arthritis: their mechanisms of action, targeted delivery, and interplay with the host microbiome

S Dudics, D Langan, RR Meka, SH Venkatesha… - International Journal of …, 2018 - mdpi.com
Rheumatoid arthritis (RA) is a chronic, debilitating illness characterized by painful swelling
of the joints, inflammation of the synovial lining of the joints, and damage to cartilage and …

Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats

Q Dai, D Zhou, L Xu, X Song - Drug design, development and …, 2018 - Taylor & Francis
Purpose Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease
characterized by aggressive and symmetric polyarthritis. Mammalian target of rapamycin …

The impact of cigarette smoking on risk of rheumatoid arthritis: a narrative review

Y Ishikawa, C Terao - Cells, 2020 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
and subsequent proliferation of synovial tissues, which eventually leads to cartilage and …

miRNAs as biomarkers and possible therapeutic strategies in rheumatoid arthritis

T Kmiołek, A Paradowska-Gorycka - Cells, 2022 - mdpi.com
Within the past years, more and more attention has been devoted to the epigenetic
dysregulation that provides an additional window for understanding the possible …

Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-α/BAFF …

R Ni, G Song, X Fu, R Song, L Li, W Pu, J Gao, J Hu… - Biomaterials, 2020 - Elsevier
Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease that results in
synovitis, cartilage destruction, and even loss of joint function. The frequent and long-term …

[HTML][HTML] Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem …

M Ghoryani, Z Shariati-Sarabi… - Biomedicine & …, 2019 - Elsevier
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune arthropathy characterized
by synovial hyperplasia leading to functional impairment. Although the exact cause of RA is …