Abstract Background and Objective: Prostate cancer is one of the most prevalent forms of
cancer in men worldwide. Traditional screening strategies such as serum PSA levels, which …

Circular RNAs (circRNAs) are noncoding and single-stranded RNA transcripts able to form
covalently circular-closed structures. They are generated through alternative splicing events …

Skin cancer is, at present, the most common type of malignancy in the Caucasian
population. Its incidence has increased rapidly in the last decade for both melanoma and …

In regards to their key role in intercellular communication, extracellular vesicles (EVs) have a
strong potential as bio-inspired drug delivery systems (DDS). With the aim of circumventing …

Objectives Giant cell arteritis (GCA) is a complex systemic vasculitis mediated by the
interplay between both genetic and epigenetic factors. Monocytes are crucial players of the …

ZHANG, Xiaohao et al. CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells
proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in …

Background The adaptation to hypoxia is mainly controlled by the HIF transcription factors.
Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients …

Diabetic nephropathy (DN) is a severe end‐stage kidney disease developed from diabetes
mellitus. The involvement of circular RNAs (circRNAs) in modulating DN pathogenesis has …

Common variable immunodeficiency (CVID), the most prevalent symptomatic primary
immunodeficiency, displays impaired terminal B-cell differentiation and defective antibody …

The mammalian genome comprehends a small minority of genes that encode for proteins
(barely 2% of the total genome in humans) and an immense majority of genes that are …