The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …
neuronal dysfunctionality which results in disability and human life-threatening events. In …
[HTML][HTML] Tangeretin attenuates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via the PI3K/Akt pathway
J Li, Q Wei, K Song, Y Wang, Y Yang, M Li… - Frontiers in …, 2023 - frontiersin.org
Background: Pulmonary fibrosis (PF) is a terminal pathological change in a variety of lung
diseases characterized by excessive deposition of extracellular matrix, for which effective …
diseases characterized by excessive deposition of extracellular matrix, for which effective …
Evaluation of the amelioration effect of Ganoderma formosanum extract on delaying PM2.5 damage to lung macrophages
Scope Particulate matter (PM) contains toxic organic matter and heavy metals that enter the
entire body through blood flow and may cause mortality. Ganoderma formosanum mycelium …
entire body through blood flow and may cause mortality. Ganoderma formosanum mycelium …
Arsenic exposure induced renal fibrosis via regulation of mitochondrial dynamics and the NLRP3‐TGF‐β1/SMAD signaling pathway
M Ren, J Li, Z Xu, B Nan, H Gao, H Wang… - Environmental …, 2024 - Wiley Online Library
Environmental arsenic exposure is one of the major global public health problems. Studies
have shown that arsenic exposure can cause renal fibrosis, but the underlying mechanism is …
have shown that arsenic exposure can cause renal fibrosis, but the underlying mechanism is …
[HTML][HTML] Tong Sai granule improves AECOPD via regulation of MAPK-SIRT1-NF-κB pathway and cellular senescence alleviation
L Tao, X Lu, Z Fu, Y Tian, X Liu, J Li, P Zhao - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Tong Sai granules (TSG) a traditional Chinese
medicine, are used to treat acute exacerbations of chronic obstructive pulmonary disease …
medicine, are used to treat acute exacerbations of chronic obstructive pulmonary disease …
[HTML][HTML] Trigonelline hydrochloride attenuates silica-induced pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation
F Zhang, H Yue, R Dong, J He, L Zhou, X Dou… - Respiratory …, 2024 - Springer
Background Silicosis represents a paramount occupational health hazard globally, with its
incidence, morbidity, and mortality on an upward trajectory, posing substantial clinical …
incidence, morbidity, and mortality on an upward trajectory, posing substantial clinical …
[HTML][HTML] Forsythoside A regulates pulmonary fibrosis by inhibiting endothelial-to-mesenchymal transition and lung fibroblast proliferation via the PTPRB signaling
Q Zhang, B Zhang, F Yang, Y Hu, R Fan, M Wang… - Phytomedicine, 2024 - Elsevier
Background Pulmonary fibrosis (PF) is an end-stage change in many interstitial lung
diseases, whereas no proven effective anti-pulmonary fibrotic treatments. Forsythoside A …
diseases, whereas no proven effective anti-pulmonary fibrotic treatments. Forsythoside A …
[HTML][HTML] Silibinin attenuates TGF-β2-induced fibrogenic changes in human trabecular meshwork cells by targeting JAK2/STAT3 and PI3K/AKT signaling pathways
X Wu, J Liang, J Liu, Y Huang, L Zhang, X Liu… - Experimental Eye …, 2024 - Elsevier
Transforming growth factor-β2 (TGF-β2) induced fibrogenic changes in human trabecular
meshwork (HTM) cells have been implicated in trabecular meshwork (TM) damage and …
meshwork (HTM) cells have been implicated in trabecular meshwork (TM) damage and …
Global Research Status and Trends of Interactions between Traditional Chinese Medicine and Pulmonary Fibrosis: A New Dawn in Treatment
B Wei, H Li, C Wang, J Hu - Available at SSRN 4724504 - papers.ssrn.com
Background: Pulmonary fibrosis (PF) remains a major sequela of COVID-19, yet its
pharmacotherapy remains unsatisfactory. Recently, Traditional Chinese medicine (TCM) …
pharmacotherapy remains unsatisfactory. Recently, Traditional Chinese medicine (TCM) …