Designing smart polymer conjugates for controlled release of payloads
Incorporating labile bonds inside polymer backbone and side chains yields interesting
polymer materials that are responsive to change of environmental stimuli. Drugs can be …
polymer materials that are responsive to change of environmental stimuli. Drugs can be …
Glycosaminoglycan‐based biohybrid hydrogels: a sweet and smart choice for multifunctional biomaterials
Glycosaminoglycans (GAGs) govern important functional characteristics of the extracellular
matrix (ECM) in living tissues. Incorporation of GAGs into biomaterials opens up new routes …
matrix (ECM) in living tissues. Incorporation of GAGs into biomaterials opens up new routes …
Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice
N Lohmann, L Schirmer, P Atallah, E Wandel… - Science translational …, 2017 - science.org
Excessive production of inflammatory chemokines can cause chronic inflammation and thus
impair cutaneous wound healing. Capturing chemokine signals using wound dressing …
impair cutaneous wound healing. Capturing chemokine signals using wound dressing …
Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry
Glycosylated α-dystroglycan (α-DG) serves as cellular entry receptor for multiple pathogens,
and defects in its glycosylation cause hereditary Walker-Warburg syndrome (WWS). At least …
and defects in its glycosylation cause hereditary Walker-Warburg syndrome (WWS). At least …
[HTML][HTML] Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: Making the right choices
Controlled, localized drug delivery is a long-standing goal of medical research, realization of
which could reduce the harmful side-effects of drugs and allow more effective treatment of …
which could reduce the harmful side-effects of drugs and allow more effective treatment of …
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate
I Vlodavsky, N Ilan, A Naggi… - Current pharmaceutical …, 2007 - ingentaconnect.com
Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …
Saccharides, oligosaccharides, and polysaccharides nanoparticles for biomedical applications
Modern requirements for designing efficient nanocarriers against diseases such as cancer
are very complex. A suitable nanocarrier should indeed remain colloidally stable in the …
are very complex. A suitable nanocarrier should indeed remain colloidally stable in the …
A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …
prompted scientists to address an urgent need for defining mechanisms of disease …
Non-anticoagulant heparins and inhibition of cancer
B Casu, I Vlodavsky, RD Sanderson - Pathophysiology of haemostasis …, 2007 - karger.com
Low-molecular-weight heparins (LMWH) appear to prolong survival of patients with cancer.
Such a beneficial effect is thought to be associated with interruption of molecular …
Such a beneficial effect is thought to be associated with interruption of molecular …
Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer
B Casu, A Naggi, G Torri - Matrix biology, 2010 - Elsevier
The heparan sulfate (HS) chains of heparan sulfate proteoglycans (HSPG) are “ubiquitous”
components of the cell surface and the extracellular matrix (EC) and play important roles in …
components of the cell surface and the extracellular matrix (EC) and play important roles in …