This review provides an overview of preclinical and clinical evidence of a role for the
neuroactive peptides cholecystokinin (CCK), corticotropin-releasing factor (CRF) …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Generalized anxiety disorder (GAD) is a relatively new diagnostic entity first defined as a
distinct category in the DSM-III. 7 Two major epidemiologic studies, the National Survey of …

Background & Aims Tachykinins are involved in physiological and pathophysiological
mechanisms in the gastrointestinal tract. The major sources of tachykinins in the gut are …

G-protein-coupled receptors (GPCRs) are crucial cell surface receptors that transmit signals
from a wide range of extracellular ligands. Indeed, 40% to 50% of all marketed drugs are …

Hydrogen sulfide (H2S) has been shown to induce transient receptor potential vanilloid 1
(TRPV1)-mediated neurogenic inflammation in polymicrobial sepsis. However, endogenous …

We have shown earlier that H2S acts as a mediator of inflammation. In this study, we have
investigated the involvement of substance P and neurogenic inflammation in H2S-induced …

Serotonin, a central neuromodulator with ancient ties to feeding and metabolism, is a major
driver of body fat loss. However, mechanisms by which central serotonin action leads to fat …

The novel NK1 receptor ligand Netupitant has been characterized in vitro and in vivo. In
calcium mobilization studies CHO cells expressing the human NK receptors responded to a …

Objective: To investigate the interaction and involvement of hydrogen sulfide and transient
receptor potential vanilloid type 1 in the pathogenesis of sepsis. Hydrogen sulfide has been …