Oxidative stress and NRF2/KEAP1/ARE pathway in diabetic kidney disease (DKD): new perspectives

DM Tanase, EM Gosav, MI Anton, M Floria… - Biomolecules, 2022 - mdpi.com
Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …

A natural products solution to diabetic nephropathy therapy

Q Hu, L Jiang, Q Yan, J Zeng, X Ma, Y Zhao - Pharmacology & Therapeutics, 2023 - Elsevier
Diabetic nephropathy is one of the most common complications in diabetes. It has been
shown to be the leading cause of end-stage renal disease. However, due to their complex …

Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation

H Li, Q Weng, S Gong, W Zhang, J Wang, Y Huang… - Food & Function, 2023 - pubs.rsc.org
Acetaminophen (APAP)-induced liver injury (AILI) has become a growing public health
problem. Ferroptosis, an iron-dependent form of cell death associated with lipid peroxide …

[HTML][HTML] Medicinal and mechanistic overview of artemisinin in the treatment of human diseases

AM Posadino, R Giordo, G Pintus… - Biomedicine & …, 2023 - Elsevier
Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has
been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial …

Old wine in new bottles: Kaempferol is a promising agent for treating the trilogy of liver diseases

X Xiao, Q Hu, X Deng, K Shi, W Zhang, Y Jiang… - Pharmacological …, 2022 - Elsevier
As a source of various compounds, natural products have long been important and valuable
for drug development. Kaempferol (KP) is the most common flavonol with bioactive activity …

Prevention of metabolic syndrome by phytochemicals and vitamin D

K Santa, Y Kumazawa, I Nagaoka - International Journal of Molecular …, 2023 - mdpi.com
In recent years, attention has focused on the roles of phytochemicals in fruits and vegetables
in maintaining and improving the intestinal environment and preventing metabolic …

Kaempferol attenuated diabetic nephropathy by reducing apoptosis and promoting autophagy through AMPK/mTOR pathways

H Sheng, D Zhang, J Zhang, Y Zhang, Z Lu… - Frontiers in …, 2022 - frontiersin.org
Introduction Renal podocyte injury, apoptosis and autophagy are involved in the occurrence
and development of diabetic nephropathy (DN). Kaempferol (KPF) has the promotion of …

Autophagy and its therapeutic potential in diabetic nephropathy

YP Han, LJ Liu, JL Yan, MY Chen, XF Meng… - Frontiers in …, 2023 - frontiersin.org
Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is the most
significant microvascular complication of diabetes and poses a severe public health concern …

Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives

P Chen, F Chen, ZL Guo, J Lei, B Zhou - Frontiers in Nutrition, 2023 - frontiersin.org
Apigenin is a bioflavonoid compound that is widely present in dietary plant foods and
possesses biological activities that protect against immune, cardiovascular, and …

Does oxidative stress management help alleviation of COVID-19 symptoms in patients experiencing diabetes?

AK Paul, MK Hossain, T Mahboob, V Nissapatorn… - Nutrients, 2022 - mdpi.com
Severe acute respiratory syndrome (SARS)-CoV-2 virus causes novel coronavirus disease
2019 (COVID-19) with other comorbidities such as diabetes. Diabetes is the most common …