Cardiovascular diseases (CVD), such as myocardial infarction (MI), constitute one of the
world's leading causes of annual deaths. This cardiomyopathy generates a tissue scar with …

Rifamycins (rifampin, rifabutin, and rifapentine) play an essential role in the treatment of
mycobacterial and some nonmycobacterial infections. They also induce the activity of …

Heparin-induced thrombocytopenia and thrombosis is a severe immune-mediated adverse
drug effect caused by the IgG antibodies to platelet factor4/heparin complexes. Activated …

Venous thromboembolism (VTE) is a prevalent yet preventable cause of death, particularly
among hospitalized patients. Studies have shown that the risk of VTE remains high for up to …

The first palladium-catalyzed Ugi-type multicomponent reaction for the synthesis of N-acyl
anthranilamides from isocyanides, 2-iodoanilines and carboxylic acids has been developed …

The drug-receptor binding kinetics are defined by the rate at which a given drug associates
with and dissociates from its binding site on its macromolecular receptor. The lead …

Univerzita Karlova, Farmaceutická fakulta v Hradci Králové Školicí pracoviště Katedra
sociální a klinické farmacie Doktorský studijní program Klinická a sociální farmacie …

Περίληψη Τα από του στόματος άμεσα δρώντα αντιπηκτικά (Direct Oral Anticoagulants–
DOACs) ήλθαν στο προσκήνιο με τη διενέργεια μεγάλων πολυκεντρικών τυχαιοποιημένων …

Сердечно-сосудистая система представляет собой совокупность органов,
обеспечивающих непрерывную циркуляцию крови в организме. Нормальной работе …

Thromboembolic events are the leading cause of morbidity and mortality worldwide. From
the second half of the 20 th century, vitamin K antagonists (VKAs), warfarin and …