Research advances on anticancer activities of matrine and its derivatives: An updated overview

H ur Rashid, Y Xu, Y Muhammad, L Wang… - European journal of …, 2019 - Elsevier
Cancer is the second leading cause of mortality, only overcome by cardiovascular diseases,
and has caused more than 8.7 million deaths in 2015 all over the world. This figure is …

Quinolizidine alkaloids derivatives from Sophora alopecuroides Linn: Bioactivities, structure-activity relationships and preliminary molecular mechanisms

Y Li, G Wang, J Liu, L Ouyang - European Journal of Medicinal Chemistry, 2020 - Elsevier
Quinolizidine alkaloids, as essential active ingredients extracted from Sophora
alopecuroides Linn, have been well concerned in the past several decades owing to the …

Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway

JS Liu, CY Huo, HH Cao, CL Fan, JY Hu, LJ Deng… - Phytomedicine, 2019 - Elsevier
Background Hepatocellular carcinoma (HCC) ranks third among the most common causes
of cancer-related deaths worldwide. The chemotherapy for HCC is still insufficient, so far. In …

[HTML][HTML] Cytisine and cytisine derivatives. More than smoking cessation aids

C Gotti, F Clementi - Pharmacological research, 2021 - Elsevier
Cytisine, a natural bioactive compound that is mainly isolated from plants of the
Leguminosae family (especially the seeds of Laburnum anagyroides), has been marketed in …

Chinese medicines for prevention and treatment of human hepatocellular carcinoma: current progress on pharmacological actions and mechanisms

X Wang, N Wang, F Cheung, L Lao, C Li… - Journal of integrative …, 2015 - Elsevier
Hepatocellular carcinoma (HCC) is one of leading causes of death in the world. Although
various treatments have been developed, the therapeutic side effects are far from desirable …

[HTML][HTML] The immunoregulatory effects of natural products on psoriasis via its action on Th17 cells versus regulatory T cells balance

L Zhong, N Luo, X Zhong, T Xu, P Hao - International …, 2022 - Elsevier
Psoriasis is an incurable, chronic inflammatory disease, which brings a substantial burden
on individuals and society. Currently, the treatment of psoriasis has entered the era of …

Matrine: Bioactivities and structural modifications

J Huang, H Xu - Current Topics in Medicinal Chemistry, 2016 - ingentaconnect.com
Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen),
Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives …

[HTML][HTML] Kaempferol and Biomodified Kaempferol from Sophora japonica Extract as Potential Sources of Anti-Cancer Polyphenolics against High Grade Glioma Cell …

JS Dos Santos, AJ Suzan, GA Bonafé… - International Journal of …, 2023 - mdpi.com
The enzymatic hydrolysis of the extract of Sophora japonica by two glycosyl hydrolases
(hesperidinase and galactosidase) was performed in order to obtain kaempferol (KPF) …

Autophagy: an overview and its roles in cancer and obesity

JA Jacob, JMM Salmani, Z Jiang, L Feng, J Song… - Clinica chimica acta, 2017 - Elsevier
Autophagy is a normal physiological process necessary for cellular homeostasis to maintain
adequate levels of cellular components. It is essential to stabilize the source of energy …

Phytochemicals in anticancer drug development

R Dutt, V Garg, N Khatri… - Anti-Cancer Agents in …, 2019 - ingentaconnect.com
Background: In spite of major technological advances in conventional therapies, cancer
continues to remain the leading cause of mortality worldwide. Phytochemicals are gradually …