Developmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos/larvae

ZG Lu, MH Li, JS Wang, DD Wei, QW Liu… - Reproductive Toxicology, 2014 - Elsevier
Matrine and sophocarpine are two major matrine-type alkaloids included in the traditional
Chinese medicine (TCM) Kushen (the root of Sophora flavescens Ait.). They have been …

A review on recent advances in aloperine research: pharmacological activities and underlying biological mechanisms

H Zhou, J Li, F Sun, F Wang, M Li, Y Dong… - Frontiers in …, 2020 - frontiersin.org
Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of
herbal plant, Sophora alopecuroides L. Empirically, Sophora alopecuroides L. is …

Characterization and Antimicrobial Activity of Alkaloid Extracts from Seeds of Different Genotypes of Lupinus spp.

FV Romeo, S Fabroni, G Ballistreri, S Muccilli, A Spina… - Sustainability, 2018 - mdpi.com
Alkaloid profiles of 22 lupin genotypes belonging to three different cultivated species,
Lupinus albus L., Lupinus luteus L., and Lupinus angustifolius L., collected from different …

[HTML][HTML] Aloperine induces G2/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells

L Zhang, Y Zheng, H Deng… - … journal of molecular …, 2014 - spandidos-publications.com
Aloperine (ALO) is a quinolizidine alkaloid extracted from the leaves of Sophora
alopecuroides (S. alopecuroides) and possesses anti-inflammatory, anti-allergenic …

Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways

Z Zhao, H Fan, T Higgins, J Qi, D Haines, A Trivett… - Cancer letters, 2014 - Elsevier
Cancer pain is a deleterious consequence of tumor growth and related inflammation.
Opioids and anti-inflammatory drugs provide first line treatment for cancer pain, but both are …

Novel bio-renewable matrinium-based ionic liquids derived from Chinese herb medicine: Synthesis, physicochemical properties and biological activity

Z Wang, J Zhang, B Lu, Y Li, Y Liang, J Yuan… - Journal of Molecular …, 2019 - Elsevier
Bio-renewable ionic liquids (ILs) have been the focus of intensive research following the
realization that commonly used ILs are not as environmentally and biologically friendly as …

Scientific opinion on the risks for animal and human health related to the presence of quinolizidine alkaloids in feed and food, in particular in lupins and lupin‐derived …

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2019 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific opinion on the risks for
animal and human health related to the presence of quinolizidine alkaloids (QA s) in feed …

Comprehensive evaluation of effective constituents in total alkaloids from Sophora alopecuroides L. and their joint action against aphids by laboratory toxicity and field …

T Ma, H Yan, X Shi, B Liu, Z Ma, X Zhang - Industrial crops and products, 2018 - Elsevier
Alkaloids are the main constituents that contributed to the insecticidal activity of plant
Sophora alopecuroides L.(Fabaceae). Using an acid extraction and alkali precipitation …

Effects of matrine on the proliferation of HT29 human colon cancer cells and its antitumor mechanism

C Chang, SP Liu, CH Fang, RS He… - Oncology …, 2013 - spandidos-publications.com
Matrine is one of the main active components that is extracted from the dry roots of Sophora
flavescens. The compound has potent antitumor activity in various cancer cell lines …

Aloperine protects mice against ischemia-reperfusion (IR)-induced renal injury by regulating PI3K/AKT/mTOR signaling and AP-1 activity

S Hu, Y Zhang, M Zhang, Y Guo, P Yang, S Zhang… - Molecular …, 2015 - Springer
Aloperine is a quinolizidine alkaloid extracted from the leaves of Sophora plants. It has been
recognized with the potential to treat inflammatory and allergic diseases as well as tumors …