Sophocarpine attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-κB activation

X Li, M Wang, H Hong, C Luo, Z Liu, R Yang - Immunologic Research, 2018 - Springer
Inflammation contributes to the pathogenesis of lupus nephritis (LN), which is the most
serious complication that increases mortality of systemic lupus erythematosus (SLE) …

Development of a highly sensitive electrochemiluminescence sophoridine sensor using Ru (bpy) 32+ integrated carbon quantum dots–polyvinyl alcohol composite …

Z Liu, X Zhang, L Cui, K Wang, H Zhan - Sensors and Actuators B …, 2017 - Elsevier
A facile electrochemiluminescence (ECL) sensing platform for the sensitive analysis of
sophoridine was constructed using Ru (bpy) 3 2+/carbon quantum dots–polyvinyl alcohol …

Oxymatrine Downregulates HPV16E7 Expression and Inhibits Cell Proliferation in Laryngeal Squamous Cell Carcinoma Hep‐2 Cells In Vitro

XJ Ying, B Jin, XW Chen, J Xie, HM Xu… - BioMed research …, 2015 - Wiley Online Library
Objective. To investigate the possible mechanisms of oxymatrine's role in anti laryngeal
squamous cell carcinoma. Methods. We examined the effects of oxymatrine on the …

A review on the pharmacology, pharmacokinetics and toxicity of sophocarpine

S Wei, J Xiao, F Ju, J Liu, Z Hu - Frontiers in Pharmacology, 2024 - frontiersin.org
Sophocarpine is a natural compound that belongs to the quinolizidine alkaloid family, and
has a long history of use and widespread distribution in traditional Chinese herbal …

Aloperine: a potent modulator of crucial biological mechanisms in multiple diseases

M Tahir, S Ali, W Zhang, B Lv, W Qiu, J Wang - Biomedicines, 2022 - mdpi.com
Aloperine is an alkaloid found in the seeds and leaves of the medicinal plant Sophora
alopecuroides L. It has been used as herbal medicine in China for centuries due to its potent …

[HTML][HTML] Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats

H Qian, J Shi, TT Fan, J Lv, SW Chen… - World Journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To explore the effect of sophocarpine on experimental liver fibrosis and the potential
mechanism involved. METHODS: Sophocarpine was injected intraperitoneally in two distinct …

A New Quinolizidine Alkaloid from Sophora flavescens

W Lei, W Xing-De, H Juan, L Gen-Tao, P Li-Yan… - Chemistry of natural …, 2014 - Springer
We studied the alkaloid constituents and bioactivity of Sophora flavescens (Leguminosae).
The constituents were isolated with silica gel column chromatography, semi-preparative …

Effect of total alkaloid extract of local Sophora alopecuroides on minimum inhibitory concentration and intracellular accumulation of ciprofloxacin, and acrA expression …

RP Jaktaji, P Mohammadi - Journal of Global Antimicrobial Resistance, 2018 - Elsevier
Objectives Multidrug-resistant phenotypes in Gram-negative bacteria such as Escherichia
coli mainly result from overexpression of the AcrAB–TolC efflux pump. Efflux pump inhibitors …

Autophagy-regulating N-heterocycles derivatives as potential anticancer agents

X Liang, L Zhang, F Li, S Luan, C He, L Yin… - Future Medicinal …, 2020 - Future Science
As a double-edged sword, autophagy in cancer cells could either suppress or promote
tumorigenesis. Nowadays, more and more natural compounds with autophagy-regulating …

[HTML][HTML] Cytisine induces apoptosis of HepG2 cells

L Yu, X Wang, ZF Chen, B Jiang… - Molecular …, 2017 - spandidos-publications.com
Cytisine is a quinolizidine alkaloid, which has been reported to be among the major
bioactive components of Sophora alopecuraides L. Quinolizidine alkaloids have previously …