[HTML][HTML] Hierarchical ultrastructure: an overview of what is known about tendons and future perspective for tendon engineering

S Zhang, W Ju, X Chen, Y Zhao, L Feng, Z Yin… - Bioactive materials, 2022 - Elsevier
Abnormal tendons are rarely ever repaired to the natural structure and morphology of
normal tendons. To better guide the repair and regeneration of injured tendons through a …

Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing

A Korcari, SJ Przybelski, A Gingery… - Connective tissue …, 2023 - Taylor & Francis
Aging is a complex and progressive process where the tissues of the body demonstrate a
decreased ability to maintain homeostasis. During aging, there are substantial cellular and …

Rejuvenation of tendon stem/progenitor cells for functional tendon regeneration through platelet-derived exosomes loaded with recombinant Yap1

J Lu, X Yang, C He, Y Chen, C Li, S Li, Y Chen, Y Wu… - Acta Biomaterialia, 2023 - Elsevier
The regenerative capabilities including self-renewal, migration and differentiation potentials
shift from the embryonic phase to the mature period of endogenous tendon stem/progenitor …

An asymmetric chitosan scaffold for tendon tissue engineering: In vitro and in vivo evaluation with rat tendon stem/progenitor cells

E Chen, L Yang, C Ye, W Zhang, J Ran, D Xue… - Acta Biomaterialia, 2018 - Elsevier
The poor healing capacity and typically incomplete regeneration of injured tendons has
made tendon repair as a primary clinical concern. Several methods for repairing injured …

The rat Achilles and patellar tendons have similar increases in mechanical properties but become transcriptionally divergent during postnatal development

D Steffen, A Avey, MJ Mienaltowski… - The Journal of …, 2023 - Wiley Online Library
The molecular events that drive post‐natal tendon development are poorly characterized. In
this study, we profiled morphological, mechanical, and transcriptional changes in the rat …

[HTML][HTML] Tendon stem/progenitor cell subpopulations and their implications in tendon biology

Z Huang, Z Yin, J Xu, Y Fei, BC Heng… - Frontiers in Cell and …, 2021 - frontiersin.org
Tendon harbors a cell population that possesses stem cell characteristics such as
clonogenicity, multipotency and self-renewal capacity, commonly referred to as tendon …

Targeting senescent tendon stem/progenitor cells to prevent or treat age-related tendon disorders

H Wang, GC Dai, YJ Li, MH Chen, PP Lu… - Stem Cell Reviews and …, 2023 - Springer
Age-related tendon disorder, a primary motor system disease, is characterized by biological
changes in the tendon tissue due to senescence and seriously affects the quality of life of the …

SM04755, a small‐molecule inhibitor of the Wnt pathway, as a potential topical treatment for tendinopathy

V Deshmukh, T Seo, AL O'Green… - Journal of …, 2021 - Wiley Online Library
The Wnt pathway is upregulated in tendinopathy, affecting inflammation and tenocyte
differentiation. Given its potential role in tendinopathy, this signaling pathway may be a …

Mesenchymal stem cells in tendon repair and regeneration: basic understanding and translational challenges

DJ Leong, HB Sun - Annals of the New York Academy of …, 2016 - Wiley Online Library
Tendon injuries are common and present a clinical challenge because they often respond
poorly to treatment and require prolonged rehabilitation. Current treatments often do not …

Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology

GV Halade, V Kain, KA Ingle - American Journal of …, 2018 - journals.physiology.org
Heart failure (HF) secondary to myocardial infarction (MI) is linked to kidney complications
that comprise cellular, structural, functional, and survival indicators. However, HF research is …