Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and
progression of various cancers. CCL2 can activate tumour cell growth and proliferation …

CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular
communication, which is crucial for the functioning of the tumor microenvironment. Although …

Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and
migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells …

The biology of solid tumors is strongly determined by the interactions of cancer cells with
their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal …

Tumors are influenced by the mechanical properties of their microenvironment. Using
patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. PDAC is only
cured by surgical resection in its early stage, but there remains a relatively high possibility of …

Pancreatic tumors are known to harbor an abundant and highly desmoplastic stroma.
Among the various cell types that reside within tumor stroma, cancer-associated fibroblasts …

Simple Summary This review depicts the principal mechanisms involved in the process of
stromal desmoplasia characterizing pancreatic ductal adenocarcinoma (PDAC). The aim of …

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer. The poor prognosis
calls for a more detailed understanding of disease biology in order to pave the way for the …