Introduction: The literature of orphan drugs and rare diseases between 2000 and 2014 is
reviewed. The overall structure of its intellectual landscape is characterized in terms of …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Objectives: This study was designed to test the safety and efficacy of pulmonary artery (PA)
denervation (PADN) for patients with idiopathic PA hypertension (IPAH) not responding …

Background—The mechanisms underlying pulmonary arterial hypertension (PAH) are
multifactorial. The efficacy of pulmonary artery denervation (PADN) for idiopathic PAH …

Pulmonary arterial hypertension (PAH) is characterized by a persistent elevation of
pulmonary arterial pressure and pulmonary arterial remodeling with unknown etiology …

Over the past several years, investigators studying nitric oxide (NO) biology and metabolism
have come to learn that the one-electron oxidation product of NO, nitrite anion, serves as a …

Abstract Aims Long noncoding RNAs (lncRNAs) are involved in the regulation of vascular
smooth muscle cells and cardiovascular pathology. However, the contribution of lncRNAs to …

L-type calcium currents conducted by Ca V 1.2 channels initiate excitation-contraction
coupling in cardiac and vascular smooth muscle. In the heart, the distal portion of the C …

The expression and function of long noncoding RNAs (lncRNAs) in the development of
hypoxic pulmonary hypertension (HPH), especially in the proliferation of pulmonary artery …

Myxomatous mitral valve disease (MMVD) causing mitral regurgitation is the most important
disease of the heart in small animal cardiovascular medicine. Because MMVD is an …