The mammalian ovary is an extremely dynamic organ in which a large majority of follicles
are effectively eliminated throughout their reproductive life. Due to the numerous efforts of …

Cell death was first described in rabbit ovaries (Graaffian follicles), the phenomenon being
called 'chromatolysis' rather than apoptosis. In humans, the ovarian endowment of …

Although the study of germ cell death is arguably still in its infancy as a field, several recent
breakthroughs have provided the fodder for a story, replete with episodes of apparent mass …

Context: Polycystic ovary syndrome (PCOS) represents the most common endocrine
abnormality in women of reproductive age. The cause of PCOS remains largely unknown …

Female mammals are endowed with a finite number of oocytes at birth, each enclosed by a
single layer of somatic (granulosa) cells in a primordial follicle 1, 2. The fate of most follicles …

Female sterility resulting from oocyte destruction is an unfortunate, and in many cases
inevitable, consequence of chemotherapy. We show that unfertilized mouse oocytes …

Obesity is associated with insulin resistance and some reproductive abnormalities.
Circulating FFAs are often elevated in obese subjects and are also closely linked to insulin …

In the mammalian ovary, follicular development and atresia are closely regulated by cell
death and survival-promoting factors, including hormones (gonadotropins) and intraovarian …

Previous studies have proposed the involvement of caspase-3, a downstream executioner
enzyme common to many paradigms of programmed cell death (PCD), in mediating the …

Members of the Bcl-2 family serve as central checkpoints for cell death regulation, and
overexpression of Bcl-2 is known to inhibit apoptosis in many cell types. To determine …