Experimental impairment of dopamine function by 6-hydroxydopamine lesions or by
dopamine receptor antagonists shows that dopamine is involved in nicotine's discriminative …

Drug dependence is a chronic, relapsing disorder in which compulsive drug-seeking and
drug-taking behaviours persist despite serious negative consequences. Addictive …

Nicotine use is a major public health problem that increases medical morbidity and mortality.
Nicotine's action and the pathobiology of schizophrenic disorders have common …

Although the molecular biology of neuronal nicotinic acetylcholine receptors (nAChRs)
provides evidence for multiple receptor subtypes, few selective pharmacological tools exist …

[2, 4]-Dimethoxybenzylidene anabaseine dihydrochloride (GTS-21), a compound that
interacts with rat neuronal nicotinic acetylcholine receptors (nAChRs), was evaluated using …

A major obstacle to the development of medications for nicotine dependence is the lack of
animal and human laboratory models with sufficient predictive clinical validity to support the …

Regulation of nicotine levels in cigarettes and other tobacco products is now possible with
the passage of the Family Smoking Prevention and Tobacco Control Act (FSPTCA) in 2009 …

Background The World Health Organization Framework Convention on Tobacco Control
(WHO FCTC) bans all forms of tobacco advertising, promotion and sponsorship. The …

Introduction: This review identified published animal studies evaluating the possible abuse
potential of acetaldehyde, nornicotine, cotinine, and anabasine based on five commonly …

Covering: up to the end of 2011 This review covers classical and modern structural
modifications of the alkaloid, the more recent (since 2007) syntheses of cytisine and …