Viruses and human cancers: a long road of discovery of molecular paradigms

MK White, JS Pagano, K Khalili - Clinical microbiology reviews, 2014 - Am Soc Microbiol
About a fifth of all human cancers worldwide are caused by infectious agents. In 12% of
cancers, seven different viruses have been causally linked to human oncogenesis: Epstein …

Towards better understanding of KSHV life cycle: from transcription and posttranscriptional regulations to pathogenesis

L Yan, V Majerciak, ZM Zheng, K Lan - Virologica Sinica, 2019 - Springer
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8
(HHV-8), is etiologically linked to the development of Kaposi's sarcoma, primary effusion …

Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS

G Zhang, B Chan, N Samarina… - Proceedings of the …, 2016 - National Acad Sciences
The latency-associated nuclear antigen (LANA) of Kaposi sarcoma herpesvirus (KSHV) is
mainly localized and functions in the nucleus of latently infected cells, playing a pivotal role …

How viruses contribute to the pathogenesis of hemophagocytic lymphohistiocytosis

E Brisse, CH Wouters, G Andrei, P Matthys - Frontiers in Immunology, 2017 - frontiersin.org
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, hyperinflammatory
syndrome, characterized by the uncontrolled activation of macrophages and T cells, eliciting …

A virus-induced circular RNA maintains latent infection of Kaposi's sarcoma herpesvirus

T Tagawa, D Oh, S Dremel, G Mahesh… - Proceedings of the …, 2023 - National Acad Sciences
Non-coding RNAs (ncRNAs) play important roles in host-pathogen interactions; oncogenic
viruses like Kaposi's sarcoma herpesvirus (KSHV) employ ncRNAs to establish a latent …

Oncolytic reovirus (pelareorep) induces autophagy in KRAS-mutated colorectal cancer

J Jiffry, T Thavornwatanayong, D Rao, EJ Fogel… - Clinical Cancer …, 2021 - AACR
Purpose: To explore the effects of pelareorep on autophagy in multiple models of colorectal
cancer, including patient-derived peripheral blood mononuclear cells (PBMCs) …

Recent advances in developing treatments of Kaposi's sarcoma herpesvirus-related diseases

E Naimo, J Zischke, TF Schulz - Viruses, 2021 - mdpi.com
Kaposi-sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) is the
causative agent of several malignancies, including Kaposi's sarcoma (KS), primary effusion …

An important role for mitochondrial antiviral signaling protein in the Kaposi's sarcoma-associated herpesvirus life cycle

JA West, M Wicks, SM Gregory, P Chugh… - Journal of …, 2014 - Am Soc Microbiol
Kaposi's sarcoma-associated herpesvirus (KSHV) has been shown to be recognized by two
families of pattern recognition receptors (PRRs), Toll-like receptors (TLRs) and NOD-like …

Implication of human herpesviruses in oncogenesis through immune evasion and supression

K Alibek, Y Baiken, A Kakpenova… - Infectious agents and …, 2014 - Springer
All human herpesviruses (HHVs) have been implicated in immune system evasion and
suppression. Moreover, two HHV family members, ie EBV and KSHV, are recognised as …

The role of viruses in HIV-associated lymphomas

K Lurain, R Ramaswami, R Yarchoan - Seminars in hematology, 2022 - Elsevier
Lymphomas are among the most common cancers in people with HIV (PWH). The
lymphoma subtypes and pathogenesis of lymphoma in PWH are different from the …