High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological
malignancy. New evidence supports a hypothesis that HGSOC can originate from fallopian …

Ovarian cancer (OC) is the leading cause of death among women with gynecologic
malignancy. Breast Cancer Susceptibility Gene 1 (BRCA 1) and Breast Cancer Susceptibility …

Ovarian cancer is a disease of older women. However, the molecular mechanisms of
ovarian aging and their contribution to the pathogenesis of ovarian cancer are currently …

Abstract c-Myc is a key oncogenic transcription factor that participates in tumor
pathogenesis. In this study, we found that levels of c-Myc mRNA and protein were higher in …

Existing evidence suggests diet and chronic inflammation as risk factors in ovarian cancer
(OC) development. We aim to conduct a meta-analysis exploring possible associations …

Background: Women with an inherited pathogenic variant in BRCA 1 or BRCA 2 have a
greatly increased risk of developing ovarian cancer, but the importance of behavioral factors …

BRCA 1 and 2 genes play a critical role in the safeguarding of DNA integrity. It is now well
established that BRCA1 and BRCA2-mutated women are at increased risk of breast and …

Evidence suggests a likely negative impact of deleterious BRCA mutations on female
fertility. Hence, different studies have aimed to address the reproductive potential and …

Highlights•Five percent of uterine and 20% of ovarian cancers are caused by germline
mutations.•There are recognised cancer predisposition syndromes causing gynaecological …

Combined estrogen–progestogen contraceptives (oral contraceptives or OCs) and
progestogen-only contraceptives (POCs) are synthetic steroids that bind to steroid hormone …