ABSTRACT A hallmark of the mammalian immune system is its ability to respond efficiently
to foreign antigens without eliciting an inappropriate response to self-antigens. Furthermore …

A subset of B cells with unique phenotypic and functional features—termed Age‐associated
B cells (ABCs)—has recently been identified in both mice and humans. These cells are …

T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells that collaborate with B
cells to promote and regulate humoral responses. Unlike other CD4+ effector lineages, Tfh …

Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by the infiltration of
exocrine glands including salivary and lachrymal glands responsible for the classical dry …

T follicular helper (Tfh) cells play key role in providing help to B cells during germinal center
(GC) reactions. Generation of protective antibodies against various infections is an important …

BCL6 is required for development of follicular T helper (Tfh) cells to support germinal center
(GC) formation. However, it is not clear what unique functions programmed by BCL6 can …

T follicular helper (Tfh) cells are specialized to provide help to B cells and to induce durable
antibody response. Our knowledge on the biology of Tfh cells and their contribution to …

Plasma cell differentiation is a tightly regulated process that requires appropriate T cell helps
to reach the induction threshold. To further understand mechanisms by which T cell inputs …

CD4+ T helper (Th) cells play an instrumental role in orchestrating adaptive immune
responses to invading pathogens through their ability to differentiate into specialized effector …

Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory
factor, PMIF, which modulates the host inflammatory response to malaria. Using a novel …