CD4+ follicular helper T cells (TFH cells) are essential for germinal center (GC) responses
and long-lived antibody responses. Here we report that naive CD4+ T cells deficient in the …

CD8+ T cells differentiate into multiple effector and memory subsets to carry out immune
clearance of infected and cancerous cells and provide long-term protection. Recent …

CD4+ T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides
help for germinal center (GC) formation, B-cell development and affinity maturation, and …

Germinal center (GC)-derived memory B cells (MBCs) are critical for humoral immunity as
they differentiate into protective antibody-secreting cells during re-infection. GC formation …

T follicular helper (Tfh) cells play critical roles for germinal center responses and effective
humoral immunity. We report here that mTOR in CD4 T cells is essential for Tfh …

Follicular helper T (Tfh) cells are essential for germinal center (GC) B cell responses.
However, it is not clear which PD-1+ CXCR5+ Bcl6+ CD4+ T cells will differentiate into PD …

High-affinity class-switched Abs and memory B cells are products of the germinal center
(GC). The CD4+ T cell help required for the development and maintenance of the GC is …

The germinal center (GC) is a unique histological structure found in peripheral lymphoid
organs. GCs provide an important source of humoral immunity by generating high affinity …

It is well established that the generation of a high‐affinity long‐lived antibody response
requires the presence of T cells, specifically CD4+ T cells. These CD4+ T cells support the …

We examined the unique contributions of the cytokines IL-21 and IL-4 on germinal center
(GC) B cell initiation and subsequent maturation in a murine model system. Similar to other …