The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Adipose tissue dysfunction occurs with aging and has systemic effects, including peripheral
insulin resistance, ectopic lipid deposition, and inflammation. Fundamental aging …

Age-related osteoporosis is characterized by the deterioration in bone volume and strength,
partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) …

Heterochronic parabiosis rejuvenates the performance of old tissue stem cells at some
expense to the young, but whether this is through shared circulation or shared organs is …

Ageing is associated with the functional decline of all tissues and a striking increase in many
diseases. Although ageing has long been considered a one-way street, strategies to delay …

The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …

Nutrients are absorbed solely by the intestinal villi. Aging of this organ causes malabsorption
and associated illnesses, yet its aging mechanisms remain unclear. Here, we show that …

Heterochronic blood sharing rejuvenates old tissues, and most of the studies on how this
works focus on young plasma, its fractions, and a few youthful systemic candidates …

Our recent study has established that young blood factors are not causal, nor necessary, for
the systemic rejuvenation of mammalian tissues. Instead, a procedure referred to as neutral …

The past two decades have seen remarkable progress in our understanding of the
multifactorial drivers of hippocampal aging and cognitive decline. Recent findings have also …