Drug‐induced toxicity is a key issue for public health because some side effects can be
severe and life‐threatening. These adverse effects can also be a major concern for the …

Contraction is crucial in maintaining the differentiated phenotype of myofibroblasts.
Contraction is an energy-dependent mechanism that relies on the production of ATP by …

Consumer and environmental safety decisions are based on exposure and hazard data,
interpreted using risk assessment approaches. The adverse outcome pathway (AOP) …

Amiodarone-associated optic neuropathy (AAON) is a complex clinical diagnosis, requiring
distinction from non-arteritic ischemic optic neuropathy (NAION) due to a shared at-risk …

Background and Purpose Amiodarone is one of the most effective anti‐arrhythmic drugs
available, but its clinical applications are limited by toxic side effects including optic toxicity …

Amiodarone, bi-iodinated benzofuran derivative, is one of the most frequently prescribed
and efficacious antiarrhythmic drugs. Despite its low incidence, amiodarone-induced …

Cardiac and extra-cardiac side effects of common antiarrhythmic agents might be related to
drug-induced mitochondrial dysfunction. Supratherapeutic doses of amiodarone have been …

Background Oxidant stress is arguably a universal feature in toxicology. Research studies
on the role of oxidant stress induced by xenobiotic exposures have typically relied on the …

Background: The fruits of Aronia melanocarpa (Michx.) Elliot is extremely rich in biologically
active polyphenols. Objective: We studied the protective effect of A. melanocarpa fruit juice …

Mitochondrial dysfunction can be a major mechanism whereby different drugs can induce
adverse effects affecting different tissues such as liver, heart and skeletal muscle. In the most …