Hepatic inflammatory responses in liver fibrosis
L Hammerich, F Tacke - Nature Reviews Gastroenterology & …, 2023 - nature.com
Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …
[HTML][HTML] Changing epidemiology, global trends and implications for outcomes of NAFLD
Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common liver
disease globally and is currently estimated to affect 38% of the global population. Only a …
disease globally and is currently estimated to affect 38% of the global population. Only a …
Randomized, controlled trial of the FGF21 analogue pegozafermin in NASH
Background Pegozafermin is a long-acting glycopegylated (pegylated with the use of site-
specific glycosyltransferases) fibroblast growth factor 21 (FGF21) analogue in development …
specific glycosyltransferases) fibroblast growth factor 21 (FGF21) analogue in development …
[HTML][HTML] The global burden of liver disease
Chronic liver disease (CLD) and its associated complications (cirrhosis and liver cancer)
cause significant mortality, morbidity, and economic burden. Published data from the World …
cause significant mortality, morbidity, and economic burden. Published data from the World …
Lifestyle interventions in nonalcoholic fatty liver disease
ZM Younossi, S Zelber-Sagi, L Henry… - Nature Reviews …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is a dynamic chronic liver disease that develops in
close association with metabolic irregularities. Between 2016 and 2019, the global …
close association with metabolic irregularities. Between 2016 and 2019, the global …
Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease
Recompensation has gained increasing attention in the field of cirrhosis, particularly in
chronic liver disease with a definite aetiology. The current global prevalence of obesity and …
chronic liver disease with a definite aetiology. The current global prevalence of obesity and …
An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH
Successful development of treatments for non-alcoholic fatty liver disease and its
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …
Hepatocellular carcinoma surveillance—Utilization, barriers and the impact of changing aetiology
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Surveillance for HCC is critical for early detection and treatment, but fewer than one-quarter …
Surveillance for HCC is critical for early detection and treatment, but fewer than one-quarter …
The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the
leading causes of chronic liver disease worldwide. NAFLD and ALD share …
leading causes of chronic liver disease worldwide. NAFLD and ALD share …
[HTML][HTML] Update on the obesity epidemic: after the sudden rise, is the upward trajectory beginning to flatten?
C Koliaki, M Dalamaga, S Liatis - Current Obesity Reports, 2023 - Springer
Abstract Purpose of Review To provide an update on current obesity prevalence trends and
summarize the available evidence suggesting a possible plateau or stabilization in obesity …
summarize the available evidence suggesting a possible plateau or stabilization in obesity …