[HTML][HTML] The presynaptic active zone

TC Südhof - Neuron, 2012 - cell.com
Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a
presynaptic nerve terminal. In this review, I discuss the molecular composition and function …

Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization

H Takahashi, AM Craig - Trends in neurosciences, 2013 - cell.com
Synapse development requires differentiation of presynaptic neurotransmitter release sites
and postsynaptic receptive apparatus coordinated by synapse organizing proteins. In …

m6A modulates neuronal functions and sex determination in Drosophila

T Lence, J Akhtar, M Bayer, K Schmid, L Spindler… - Nature, 2016 - nature.com
Abstract N 6-methyladenosine RNA (m6A) is a prevalent messenger RNA modification in
vertebrates. Although its functions in the regulation of post-transcriptional gene expression …

[HTML][HTML] RNA localization is a key determinant of neurite-enriched proteome

A Zappulo, D Van Den Bruck, C Ciolli Mattioli… - Nature …, 2017 - nature.com
Protein subcellular localization is fundamental to the establishment of the body axis, cell
migration, synaptic plasticity, and a vast range of other biological processes. Protein …

LAR-RPTPs: synaptic adhesion molecules that shape synapse development

JW Um, J Ko - Trends in cell biology, 2013 - cell.com
The synapse is the most elementary operating unit in neurons, creating neural circuits that
underlie all brain functions. Synaptic adhesion molecules initiate neuronal synapse …

[HTML][HTML] Synapse development and maturation at the drosophila neuromuscular junction

VT Chou, SA Johnson, D Van Vactor - Neural development, 2020 - Springer
Synapses are the sites of neuron-to-neuron communication and form the basis of the neural
circuits that underlie all animal cognition and behavior. Chemical synapses are specialized …

A syndromic neurodevelopmental disorder caused by rare variants in PPFIA3

MS Paul, SL Michener, H Pan, H Chan… - The American Journal of …, 2024 - cell.com
PPFIA3 encodes the protein-tyrosine phosphatase, receptor-type, F-polypeptide-interacting-
protein-alpha-3 (PPFIA3), which is a member of the LAR-protein-tyrosine phosphatase …

Molecular organization and plasticity of the cytomatrix at the active zone

ED Gundelfinger, A Fejtova - Current opinion in neurobiology, 2012 - Elsevier
Regulated neurotransmitter release from presynaptic boutons is crucial for the functioning of
chemical synapses, what in turn governs the functional performance of the nervous system …

Cellular and molecular mechanisms underlying presynapse formation

PH Chia, P Li, K Shen - Journal of Cell Biology, 2013 - rupress.org
Synapse formation is a highly regulated process that requires the coordination of many cell
biological events. Decades of research have identified a long list of molecular components …

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission

SA Spangler, SK Schmitz, JT Kevenaar… - Journal of Cell …, 2013 - rupress.org
The presynaptic active zone mediates synaptic vesicle exocytosis, and modulation of its
molecular composition is important for many types of synaptic plasticity. Here, we identify …