Evaluation of high‐density lipoprotein‐bound long non‐coding RNAs in subjects with familial hypercholesterolaemia

R Scicali, G Bosco, A Scamporrino… - European Journal of …, 2024 - Wiley Online Library
Abstract Background Long non‐coding RNAs (lncRNAs) could be attractive circulating
biomarkers for cardiovascular risk stratification in subjects at high atherosclerotic …

Familial hypercholesterolemia and elevated lipoprotein (a): cascade testing and other implications for contextual models of care

WJ Loh, DC Chan, P Mata, GF Watts - Frontiers in Genetics, 2022 - frontiersin.org
Elevated lipoprotein (a)[Lp (a)], a predominantly genetic disorder, is a causal risk factor for
atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valvular disease …

Molecular therapies in cardiovascular diseases: Small interfering RNA in atherosclerosis, heart failure, and hypertension

R Sarzani, F Spannella, C Di Pentima… - International Journal of …, 2023 - mdpi.com
Small interfering RNA (siRNA) represents a novel, fascinating therapeutic strategy that
allows for selective reduction in the production of a specific protein through RNA …

Heterogeneity of lipoprotein (a) levels among Hispanic or Latino individuals residing in the US

PH Joshi, S Marcovina, K Orroth, JAG López… - JAMA …, 2023 - jamanetwork.com
Importance Lipoprotein (a)(Lp [a]) is a genetically determined risk-enhancing factor for
atherosclerotic cardiovascular disease (ASCVD). The Lp (a) distribution among the diverse …

Plasminogen receptors promote lipoprotein (a) uptake by enhancing surface binding and facilitating macropinocytosis

H Siddiqui, N Deo, MT Rutledge… - … and Vascular Biology, 2023 - Am Heart Assoc
BACKGROUND: High levels of Lp (a)(lipoprotein (a)) are associated with multiple forms of
cardiovascular disease. Lp (a) consists of an apoB100-containing particle attached to the …

Updates in small interfering RNA for the treatment of dyslipidemias

S Carugo, CR Sirtori, G Gelpi, A Corsini… - Current Atherosclerosis …, 2023 - Springer
Abstract Purpose of Review Atherosclerotic cardiovascular disease (ASCVD) is still the
leading cause of death worldwide. Despite excellent pharmacological approaches, clinical …

A systematic review on the risk modulators of myocardial infarction in the “young”—Implications of Lipoprotein (a)

C Stătescu, L Anghel, LC Benchea… - International Journal of …, 2023 - mdpi.com
The presence of a myocardial infarction at a younger age is of special interest, considering
the psychological and socioeconomic impact, as well as long-term morbidity and mortality …

Reducing saturated fat intake lowers LDL-C but increases Lp (a) levels in African Americans: the GET-READI feeding trial

HG Law, MA Khan, W Zhang, H Bang, J Rood… - Journal of Lipid …, 2023 - ASBMB
Reducing dietary saturated fatty acids (SFA) intake results in a clinically significant lowering
of low-density lipoprotein cholesterol (LDL-C) across ethnicities. In contrast, dietary SFA's …

[HTML][HTML] An update on inflammation in atherosclerosis: how to effectively treat residual risk

N Mohammadnia, TSJ Opstal, S El Messaoudi… - Clinical …, 2023 - Elsevier
Purpose This study reviewed the contribution of inflammation to atherosclerotic
cardiovascular disease (ASCVD), which has gained widespread recognition in recent years …

[HTML][HTML] Is there a benefit of aspirin therapy for primary prevention to reduce the risk of atherosclerotic cardiovascular disease in patients with elevated Lipoprotein (a) …

MH Sukkari, B Al-Bast, R Al Tamimi, W Giesing… - American Journal of …, 2023 - Elsevier
Aspirin has long been recognized as a beneficial treatment for atherosclerotic
cardiovascular disease (ASCVD) due to its antiplatelet effects. However, there is a need to …