Omics insights into extracellular vesicles in embryo implantation and their therapeutic utility

QH Poh, A Rai, LA Salamonsen, DW Greening - Proteomics, 2023 - Wiley Online Library
Implantation success relies on intricate interplay between the developing embryo and the
maternal endometrium. Extracellular vesicles (EVs) represent an important player of this …

The role of extracellular vesicles in endometrial receptivity and their potential in reproductive therapeutics and diagnosis

AR Hart, NLA Khan, K Godakumara, K Dissanayake… - Reproductive …, 2022 - Elsevier
abstract Extracellular vesicles (EVs) are small, nanometre sized, membrane-enclosed
structures released by cells and are thought to be crucial in cellular communication. The …

Embryonic microRNAs are essential for bovine preimplantation embryo development

EE Paulson, EL Fishman, J Ma… - Proceedings of the …, 2022 - National Acad Sciences
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression after
transcription. miRNAs are present in transcriptionally quiescent full-grown oocytes and …

Rapid generation of functional nanovesicles from human trophectodermal cells for embryo attachment and outgrowth

QH Poh, A Rai, M Pangestu, LA Salamonsen… - …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are important mediators of embryo attachment and outgrowth
critical for successful implantation. While EVs have garnered immense interest in their …

Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development

R Mazzarella, K Cañón-Beltrán, YN Cajas… - Journal of Animal …, 2024 - Springer
Abstract Background Extracellular vesicles (EVs) present in oviductal (OF) and uterine fluid
(UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing …

New roles for EVs, miRNA and lncRNA in bovine embryo implantation

K Imakawa, Y Matsuno, H Fujiwara - Frontiers in veterinary science, 2022 - frontiersin.org
The sine qua non of new life is fertilization. However, approximately 50% of fertilized
eggs/blastocysts in cattle and up to 75% of those from human assisted reproductive …

Endothelial extracellular vesicles enriched in microRNA-34a predict new-onset diabetes in COVID-19 patients: novel insights for long-COVID metabolic sequelae

P Mone, SS Jankauskas, MV Manzi… - … of Pharmacology and …, 2024 - ASPET
Emerging evidence indicates that the relationship between COVID-19 and diabetes is
twofold: 1) it is known that the presence of diabetes and other metabolic alterations poses a …

Oocyte developmental capacity is influenced by intrinsic ovarian factors in a bovine model for individual embryo production

N Azari-Dolatabad, C Benedetti, DA Velez… - Animal Reproduction …, 2023 - Elsevier
The ovary and its hormones may have major effects on the in vitro developmental capacity of
the oocytes it contains. We related intrinsic ovarian factors namely the presence of corpus …

Effect of blastocyst development on hatching and embryo implantation

M Ma, L Zhang, Z Liu, Y Teng, M Li, X Peng, L An - Theriogenology, 2023 - Elsevier
The mammalian zygote, formed after a sperm fertilizes an egg, undergoes several rounds of
mitosis and morphogenesis to form the blastocyst. During the peri-implantation period, the …

Recent progress of interferon-tau research and potential direction beyond pregnancy recognition

H Bai, M Kawahara, M Takahashi… - Journal of Reproduction …, 2022 - jstage.jst.go.jp
Since the discovery of interferon-tau (IFNT) over 30 years ago as the trophectodermal
cytokine responsible for the maintenance of the maternal corpus luteum (CL) in ruminants …