The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy

C Shi, K Qin, A Lin, A Jiang, Q Cheng, Z Liu… - Journal of Experimental …, 2022 - Springer
As our understanding of the mechanisms of cancer treatment has increased, a growing
number of studies demonstrate pathways through which DNA damage repair (DDR) affects …

Therapeutic strategies to enhance tumor antigenicity: making the tumor detectable by the immune system

D Meraviglia-Crivelli, A Zheleva, M Barainka, B Moreno… - Biomedicines, 2022 - mdpi.com
Cancer immunotherapy has revolutionized the oncology field, but many patients still do not
respond to current immunotherapy approaches. One of the main challenges in broadening …

Apigeninidin-enriched Sorghum bicolor (L. Moench) extracts alleviate Aflatoxin B1-induced dysregulation of male rat hypothalamic-reproductive axis

SE Owumi, MT Otunla, UO Arunsi… - … Biology and Medicine, 2022 - journals.sagepub.com
We examined the protective effect of the apigeninidin (API)-enriched fraction from Sorghum
bicolor sheaths extracts (SBE-05, SBE-06, and SBE-07) against aflatoxin B1 (AFB1)-induced …

[HTML][HTML] Contribution of common plastic-related endocrine disruptors to epithelial-mesenchymal transition (EMT) and tumor progression

M Pesonen, K Vähäkangas - Chemosphere, 2022 - Elsevier
Many chemicals, including many endocrine disruptors (EDCs) are known to leach out from
various plastic consumer products and waste, and are widespread in the environment …

[PDF][PDF] Mechanistic insight into the bioactivity of prodigiosin-entrapped lipid nanoparticles against triple-negative breast, lung and colon cancer cell lines

TH Gugu, CO Eze, FC Kenechukwu, MAKM Bintang… - Heliyon, 2023 - cell.com
This research investigates the potentials of prodigiosin (PG) derived from bacteria and its
formulations against triple-negative breast (TNB), lung, and colon cancer cells. The PG was …

[HTML][HTML] Case report: malignant melanoma associated with COVID-19: a coincidence or a clue?

AA Leis, AP Montesi, SM Khan, M Montesi - Frontiers in Medicine, 2022 - frontiersin.org
Following SARS-CoV-2 infection in humans, there is upregulation of proinflammatory
molecules S100 calcium binding protein B (S100B), high-mobility group box-1 (HMGB1) …

[HTML][HTML] Bacterial immunotherapy: is it a weapon in our arsenal in the fight against cancer?

S Sharma, H Sharma, H Gogoi - Frontiers in Immunology, 2023 - frontiersin.org
Advances in understanding the genetic basis of cancer have driven alternative treatment
approaches. Recent findings have demonstrated the potential of bacteria and it's …

Exposure to polycyclic aromatic hydrocarbons promotes the progression of low‐grade cervical intraepithelial neoplasia: A population‐based cohort study in China

M Cui, L Song, R Mao, Y Lyu, L Ding… - … Journal of Cancer, 2024 - Wiley Online Library
Low‐grade cervical intraepithelial neoplasia (CIN1) is an early stage of cervical cancer
development. Previously, we reported that exposure to polycyclic aromatic hydrocarbons …

Antitumor activity of Urtica dioica seed extract on diethylnitrosamine-induced liver carcinogenesis in rats

Ö Keleş, Z Huyut, M Arslan, K Yıldızhan… - Indian Journal of …, 2024 - avesis.yyu.edu.tr
Hepatocellular carcinoma (HCC) is a significant health problem for human life; therefore,
new therapeutic approaches are essential. In vitrostudies have shown that the extract …

Genes and the Environment in Cancer: Focus on Environmentally Induced DNA Methylation Changes

F Coppedè - Cancers, 2023 - mdpi.com
Cancer has traditionally been viewed as a genetic disorder resulting from the accumulation
of gene mutations, chromosomal rearrangements, and aneuploidies in somatic cells …