Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome's integrity, whether as a consequence of …

Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of
epigenetic influence on human traits and disease. In addition to influences of age and …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common human
malignancy in the world, with high mortality and poor prognosis for patients. Among the risk …

Non-small cell lung carcinoma (NSCLC) is the most common malignancy worldwide. The
signaling cascades are stimulated via genetic modifications in upstream signaling …

DNA methylation is an epigenetic modification involved in gene expression regulation. In
cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …

Microplastic (MP) pollution has become a major global concern due to the widespread use
and discharge of plastics into the environment. However, very few studies have assessed …

DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Modifications of epigenetic factors affect our lives and can give important information
regarding one's state of health. In cancer, epigenetic modifications play a crucial role, as …

Introduction: Head and neck squamous cell carcinoma (HNSCC) is a devastating and
deadly disease, largely because it is diagnosed in late stage. Cure rates, currently at 50 …