Effect of Statins on Serum level of hs‐CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta‐Analysis of Randomized Controlled …
T Kandelouei, M Abbasifard, D Imani… - Mediators of …, 2022 - Wiley Online Library
Background. Several studies have reported that statins have anti‐inflammatory effects.
Nevertheless, results of clinical trials concerning the effect of statins on the levels of C …
Nevertheless, results of clinical trials concerning the effect of statins on the levels of C …
Lipid metabolism, apoptosis and cancer therapy
C Huang, C Freter - International journal of molecular sciences, 2015 - mdpi.com
Lipid metabolism is regulated by multiple signaling pathways, and generates a variety of
bioactive lipid molecules. These bioactive lipid molecules known as signaling molecules …
bioactive lipid molecules. These bioactive lipid molecules known as signaling molecules …
[HTML][HTML] Pleiotropic effects of statins: A focus on cancer
Abstract The statin drugs ('statins') potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-
CoA) reductase by competitively blocking the active site of the enzyme. Statins decrease de …
CoA) reductase by competitively blocking the active site of the enzyme. Statins decrease de …
Pharmacological actions of statins: a critical appraisal in the management of cancer
P Gazzerro, MC Proto, G Gangemi, AM Malfitano… - Pharmacological …, 2012 - ASPET
Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …
Cholesterol and its metabolites in tumor growth: therapeutic potential of statins in cancer treatment
A Chimento, I Casaburi, P Avena, F Trotta… - Frontiers in …, 2019 - frontiersin.org
Cholesterol is essential for cell function and viability. It is a component of the plasma
membrane and lipid rafts and is a precursor for bile acids, steroid hormones, and Vitamin D …
membrane and lipid rafts and is a precursor for bile acids, steroid hormones, and Vitamin D …
The statins as anticancer agents
Hydroxy-3-methylgutaryl CoA reductase inhibitors, commonly referred to as the statins, have
proven therapeutic and preventative effects in cardiovascular diseases. Recently, there are …
proven therapeutic and preventative effects in cardiovascular diseases. Recently, there are …
HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis
The statin family of drugs target HMG-CoA reductase, the rate-limiting enzyme of the
mevalonate pathway, and have been used successfully in the treatment of …
mevalonate pathway, and have been used successfully in the treatment of …
The role of statins in cancer therapy
K Hindler, CS Cleeland, E Rivera, CD Collard - The oncologist, 2006 - academic.oup.com
Learning Objectives After completing this course, the reader will be able to: Explain how
statins, used in the treatment of hypercholesterolemia, may be applicable to cancer …
statins, used in the treatment of hypercholesterolemia, may be applicable to cancer …
Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention
H Mo, CE Elson - Experimental biology and medicine, 2004 - journals.sagepub.com
Pools of farnesyl diphosphate and other phosphorylated products of the mevalonate
pathway are essential to the post-translational processing and physiological function of …
pathway are essential to the post-translational processing and physiological function of …
Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux
C Riganti, E Miraglia, D Viarisio, C Costamagna… - Cancer research, 2005 - AACR
Multidrug resistance (MDR) is a phenomenon by which cancer cells evade the cytotoxic
effects of chemotherapeutic agents. It may occur through different mechanisms, but it often …
effects of chemotherapeutic agents. It may occur through different mechanisms, but it often …