Background. Several studies have reported that statins have anti‐inflammatory effects.
Nevertheless, results of clinical trials concerning the effect of statins on the levels of C …

Lipid metabolism is regulated by multiple signaling pathways, and generates a variety of
bioactive lipid molecules. These bioactive lipid molecules known as signaling molecules …

Abstract The statin drugs ('statins') potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-
CoA) reductase by competitively blocking the active site of the enzyme. Statins decrease de …

Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

Cholesterol is essential for cell function and viability. It is a component of the plasma
membrane and lipid rafts and is a precursor for bile acids, steroid hormones, and Vitamin D …

Hydroxy-3-methylgutaryl CoA reductase inhibitors, commonly referred to as the statins, have
proven therapeutic and preventative effects in cardiovascular diseases. Recently, there are …

The statin family of drugs target HMG-CoA reductase, the rate-limiting enzyme of the
mevalonate pathway, and have been used successfully in the treatment of …

Learning Objectives After completing this course, the reader will be able to: Explain how
statins, used in the treatment of hypercholesterolemia, may be applicable to cancer …

Pools of farnesyl diphosphate and other phosphorylated products of the mevalonate
pathway are essential to the post-translational processing and physiological function of …

Multidrug resistance (MDR) is a phenomenon by which cancer cells evade the cytotoxic
effects of chemotherapeutic agents. It may occur through different mechanisms, but it often …