Next to its well-studied toxicity, carbon monoxide (CO) is recognized as a signalling
molecule in various cellular processes. Thus, CO-releasing molecules (CORMs) are of …

Objective When using observational data to estimate the causal effects of a treatment on
clinical outcomes, we need to adjust for confounding. In the presence of time-dependent …

OBJECTIVE Delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) may
result in focal neurological deficits and cerebral infarction, believed to result from critical …

Sanguinate is a unique polyethylene glycol modified form of bovine hemoglobin that
represents the latest generation of hemoglobin-based oxygen carriers. Its structural …

This review of 2017 publications identifies side effects of blood, blood components, and
covers plasma products. Additionally, albumin, blood transfusion (erythrocytes …

The assessment of low‐dose carbon monoxide (CO) as a therapeutic in the clinic is unique
because of the diversity of data of the effects of low‐dose CO in humans. This chapter …

BACKGROUND PP‐007 is a polyethylene glycol (PEG) ylated bovine carboxyhemoglobin
gas transfer molecule with pleotropic cytoprotective effects, vasodilatation, plasma …

Patients who decline blood transfusion on the basis of religious belief, such as Jehovah's
Witnesses, pose unique management dilemmas and opportunities for healthcare. In …

Transfusion of erythrocytes (RBC) to treat acute or chronic anemia has significant
drawbacks, given the risks of transfusion, volunteer donor requirements, limited supply with …

Normally, cerebral blood flow (CBF) is maintained by cerebral autoregulation at about 50 mL
blood/100 g brain/min. In acute ischaemic stroke, a cerebral artery is occluded or there is a …