In humans, the cytosolic glutathione S-transferase (GST) family of proteins is encoded by 16
genes presented in seven different classes. GSTs exhibit remarkable structural similarity …

Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Disturbed redox homeostasis represents a hallmark of cancer phenotypes, affecting cellular
metabolism and redox signaling. Since reactive oxygen and nitrogen species (ROS/RNS) …

Simple Summary Despite an initial response to therapy, many lung cancer patients
inevitably develop resistance to therapy leading to decreased duration of response and …

The isoenzyme of human glutathione transferase P1-1 (hGSTP1-1) is involved in multi-drug
resistance (MDR) mechanisms in numerous cancer cell lines. In the present study, the …

Hepatocellular carcinoma (HCC) metabolism is redirected to glycolysis to enhance the
production of metabolic compounds employed by cancer cells to produce proteins, lipids …

Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …

Multidrug resistance (MDR) promotes tumor recurrence and metastasis and heavily reduces
anticancer efficiency, which has become a primary reason for the failure of clinical …

Objective The first-line chemotherapy for ovarian cancer is based on a combination of
platinum and taxane. To date, no reliable predictive biomarker has been recognized that is …