[HTML][HTML] Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer

J Chen, Y Wu, X Luo, D Jin, W Zhou, Z Ju, D Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Tumor metastasis of colorectal cancer (CRC) is the main cause of death in
most patients and the major difficulty in comprehensive CRC treatment. Circular RNAs …

[HTML][HTML] Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis

S Liu, X Jiang, X Cui, J Wang, S Liu, H Li, J Yang… - Cell Death & …, 2021 - nature.com
Human antigen R (HuR) is a widespread RNA-binding protein involved in homeostatic
regulation and pathological processes in many diseases. Atherosclerosis is the leading …

Chemokines in bone-metastatic breast cancer: Therapeutic opportunities

Y Wang, S Ren, Z Wang, Z Wang, N Zhu, D Cai… - International …, 2020 - Elsevier
Due to non-response to chemotherapy, incomplete surgical resection, and resistance to
checkpoint inhibitors, breast cancer with bone metastasis is notoriously difficult to cure …

[HTML][HTML] circEPB41L2 blocks the progression and metastasis in non-small cell lung cancer by promoting TRIP12-triggered PTBP1 ubiquitylation

Y Wang, Y Wang, C Wu, Y Ji, P Hou, X Wu, Z Li… - Cell Death …, 2024 - nature.com
The metastasis of non-small cell lung cancer (NSCLC) is the leading death cause of NSCLC
patients, which requires new biomarkers for precise diagnosis and treatment. Circular RNAs …

HuR promotes ovarian cancer cell proliferation by regulating TIMM44 mRNA stability

X Yu, Y Li, Y Ding, H Zhang, N Ding, M Lu - Cell Biochemistry and …, 2020 - Springer
The human antigen R (HuR) could play an essential role in stabilizing the mRNAs of many
tumor-associated genes. Little research is performed to investigate the relevant mechanism …

[HTML][HTML] Identification of TRIM25 as a negative regulator of caspase-2 expression reveals a novel target for sensitizing colon carcinoma cells to intrinsic apoptosis

U Nasrullah, K Haeussler, A Biyanee, I Wittig… - Cells, 2019 - mdpi.com
Colorectal cancer (CRC) is one of the most common cancers that is characterized by a high
mortality due to the strong metastatic potential of the primary tumor and the high rate of …

[HTML][HTML] HuR promotes the progression of gastric cancer through mediating CDC5L expression

J Cui, N Cao, G Wang, F Wang, B Yang, J Wang… - Disease …, 2022 - hindawi.com
Background and Objectives. Gastric cancer (GC) is one of the common gastrointestinal
tumors and the third in the mortality rate among tumors. Studies have shown that the human …

[HTML][HTML] HLA complex group 11 is involved in colorectal carcinoma cisplatin resistance via the miR‑214‑5p/SOX4 axis

J Xie, J Zhu, J Pang, Y Ma - Oncology Letters, 2021 - spandidos-publications.com
The aim of the present study was to investigate the roles and potential mechanisms of long
non‑coding RNA HLA complex group 11 (HCG11) in colorectal carcinoma. Reverse …

[HTML][HTML] The Function and Prognostic Value of RNA-Binding Proteins in Colorectal Adenocarcinoma Were Analyzed Based on Bioinformatics of Smart Medical Big …

H Zhao, P Wang, H Liu, Y Li, Q Luo, M Li… - Journal of Healthcare …, 2021 - hindawi.com
Colon cancer is the third most frequent cancer in the world and is mainly adenocarcinoma in
terms of pathological type. It has been confirmed that the dysregulation of RNA-binding …

HuR/miR-124-3p/VDR complex bridges lipid metabolism and tumor development in colorectal cancer

F Huang, L Bu, M Li, Y Wang, R Zhang, Y Shao, K Lin… - 2023 - researchsquare.com
Background: Maintaining lipid homeostasis to prevent lipotoxicity is crucial for various
tumors, including colorectal cancer (CRC). Hu-antigen R (HuR) is a member of the RNA …