Purpose This review provides a current perspective on the mechanism of vitamin D on
skeletal muscle function with the emphasis on oxidative stress, muscle anabolic state and …

A large number of mutations in genes that encode RNA binding proteins cause human
disease. Many of these RNA binding proteins mediate key steps in post-transcriptional …

While the importance of RNA localization in highly differentiated cells is well appreciated,
basic principles of RNA localization in skeletal muscle remain poorly characterized. Here …

Little information is available about how post-transcriptional mechanisms regulate the aging
process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a …

Polyadenylation is the RNA processing step that completes the maturation of nearly all
eukaryotic mRNAs. It is a two-step nuclear process that involves an endonucleolytic …

Age-related muscle loss impacts on whole-body metabolism and leads to frailty and
sarcopenia, which are risk factors for fractures and mortality. Although nutrients are integral …

Non-coding CGG repeat expansions cause multiple neurodegenerative disorders, including
fragile X-associated tremor/ataxia syndrome, neuronal intranuclear inclusion disease …

Occurring in over 60% of human genes, alternative polyadenylation (APA) results in
numerous transcripts with differing 3'ends, thus greatly expanding the diversity of mRNAs …

Growing oocytes store a large amount of maternal mRNA to support the subsequent
“maternal-zygotic transition” process. At present, it is not clear how the growing oocytes store …

Embryonic myogenesis is a temporally and spatially regulated process that generates
skeletal muscle of the trunk and limbs. During this process, mononucleated myoblasts …