Abstract Glutathione peroxidase 4 (GP x4) is the only enzyme capable of reducing toxic lipid
hydroperoxides in biological membranes to the corresponding alcohols using glutathione as …

Background: Ferroptosis is a newly discovered form of iron-dependent oxidative cell death
characterized by lethal accumulation of lipid-based reactive oxygen species (ROS). It is …

The peroxidation of unsaturated fatty acids is a widely recognized metabolic process that
creates a complex mixture of volatile organic compounds including aldehydes. Elevated …

Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is the only known intracellular
antioxidant enzyme that can directly reduce lipid hydroperoxide in membrane. Mitochondrial …

Ca 2+ ions play a fundamental role in cell death mediated by oxidative glutamate toxicity or
oxytosis, a form of programmed cell death similar and possibly identical to other forms of cell …

Cancer cells produce high amounts of reactive oxygen species (ROS) and evade apoptosis.
Hydroperoxides support proliferation, invasion, migration and angiogenesis, but at higher …

Abstract Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in
mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4) …

Type 2 diabetes mellitus (T2DM) is the most common human endocrine disease and is
characterized by peripheral insulin resistance and pancreatic islet β‐cell failure …

Glutathione peroxidase 4 (Gpx4) is an antioxidant defense enzyme important in reducing
hydroperoxides in membrane lipids and lipoproteins. Gpx4 is essential for survival of …

LUBAC-mediated linear ubiquitination plays a pivotal role in regulation of cell death and
inflammatory pathways. Genetic deficiency in LUBAC components leads to severe immune …