Monocytes and macrophages in spondyloarthritis: functional roles and effects of current therapies

S Martínez-Ramos, C Rafael-Vidal, JM Pego-Reigosa… - Cells, 2022 - mdpi.com
Spondyloarthritis (SpA) is a family of chronic inflammatory diseases, being the most
prevalent ankylosing spondylitis (AS) and psoriatic arthritis (PsA). These diseases share …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles as non-coding RNA therapeutic vehicles in autoimmune diseases

O Martinez-Arroyo, A Ortega, MJ Forner, R Cortes - Pharmaceutics, 2022 - mdpi.com
Pharmaceutics | Free Full-Text | Mesenchymal Stem Cell-Derived Extracellular Vesicles as
Non-Coding RNA Therapeutic Vehicles in Autoimmune Diseases Next Article in Journal …

S100A8 and S100A12 proteins as biomarkers of high disease activity in patients with Rheumatoid Arthritis that can be regulated by epigenetic drugs

L Roszkowski, B Jaszczyk, M Plebańczyk… - International Journal of …, 2022 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease that is still not
well understood in terms of its pathogenesis and presents diagnostic and therapeutic …

[HTML][HTML] Circulating miRNA-19b as a biomarker of disease progression and treatment response to baricitinib in rheumatoid arthritis patients through miRNA profiling of …

M Ciechomska, L Roszkowski, T Burakowski… - Frontiers in …, 2023 - frontiersin.org
Introduction A number of studies have demonstrated a key role of miRNA isolated from cells,
tissue or body fluids as disease-specific biomarkers of autoimmune rheumatic diseases …

Synovial monocytes contribute to chronic inflammation in childhood-onset arthritis via IL-6/STAT signalling and cell-cell interactions

T Schmidt, A Dahlberg, E Berthold, P Król… - Frontiers in …, 2023 - frontiersin.org
Introduction Monocytes are key effector cells in inflammatory processes. We and others have
previously shown that synovial monocytes in childhood-onset arthritis are activated …

[HTML][HTML] Baricitinib therapy response in rheumatoid arthritis patients associates to STAT1 phosphorylation in monocytes

G Tucci, C Garufi, I Pacella, M Zagaglioni… - Frontiers in …, 2022 - frontiersin.org
Baricitinib is a Janus kinase (JAK) 1 and 2 inhibitor approved for treating rheumatoid arthritis
(RA). The JAK/STAT system is essential in the intracellular signaling of different cytokines …

Efficient treatment of rheumatoid arthritis by degradable LPCE nano-conjugate-delivered p65 siRNA

X Chen, B Zhou, Y Gao, K Wang, J Wu, M Shuai, K Men… - Pharmaceutics, 2022 - mdpi.com
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases worldwide,
causing severe cartilage damage and disability. Despite the recent progress made in RA …

Transcriptomic profile comparison of monocytes from rheumatoid arthritis patients in treatment with methotrexate, anti-TNFa, abatacept or tocilizumab

M Talmon, M Percio, JA Obeng, FA Ruffinatti, D Sola… - PLoS …, 2023 - journals.plos.org
It is well documented that patients affected by rheumatoid arthritis (RA) have distinct
susceptibility to the different biologic DMARDs available on the market, probably because of …

α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome …

YJ Wu, SS Zhang, Q Yin, M Lei, QH Wang… - Drug Design …, 2023 - Taylor & Francis
Background α-Mangostin (MG) showed the potentials in alleviating experimental arthritis,
inhibiting inflammatory polarization of macrophages/monocytes, and regulating peroxisome …

Immunomodulatory effects of curcumin on macrophage polarization in rheumatoid arthritis

T Deng, J Xu, Q Wang, X Wang, Y Jiao… - Frontiers in …, 2024 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by synovial
inflammation, cartilage destruction, pannus formation and bone erosion. Various immune …