Neutrophils (also named polymorphonuclear leukocytes or PMN) are essential components
of the immune system, rapidly recruited to sites of inflammation, providing the first line of …

Glucocorticoids are widely used for the management of inflammatory diseases. Their clinical
application stems from our understanding of the inhibitory effect of the corticosteroid …

Epithelial restitution is an essential process that is required to repair barrier function at
mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in …

Annexin A1 is a 37 kDa phospholipid-binding protein that is expressed in many tissues and
cell types, including leukocytes, lymphocytes and epithelial cells. Although Annexin A1 has …

Chronic diseases that affect our society are made more complex by comorbidities and are
poorly managed by the current pharmacology. While all present inflammatory …

Polymorphonuclear leukocyte (PMN)–derived microparticles display inhibitory properties on
target cells as assessed in vitro; since PMNs contain abundant amounts of the endogenous …

We discuss the fascinating pharmacology of formylpeptide receptor 2 (FPR2; often referred
to as FPR2/ALX since it binds lipoxin A4). Initially identified as a low‐affinity 'relative'of …

Inflammation is the body's way of defending itself against noxious stimuli and pathogens.
Under normal circumstances, the body is able to eliminate the insult and subsequently …

Annexin A1 is a mediator of natural and glucocorticoid-induced resolution of inflammation,
with profound effects on neutrophil apoptosis in vivo. This study aimed at assessing whether …

Annexin A1 (ANXA1) is a Ca2+-regulated phospholipid-binding protein involved in various
cell processes. ANXA1 was initially widely studied in inflammation resolution, but its …