Drug resistance in nontuberculous mycobacteria: mechanisms and models

S Saxena, HP Spaink, G Forn-Cuní - Biology, 2021 - mdpi.com
Simple Summary Recently, there has been a considerable rise in infections caused by
nontuberculous mycobacteria (NTM). These mycobacteria, which comprise a large and …

Mycobacterium abscessus: It's Complex

HFM Abdelaal, ED Chan, L Young, SL Baldwin… - Microorganisms, 2022 - mdpi.com
Mycobacterium abscessus (M. abscessus) is an opportunistic pathogen usually colonizing
abnormal lung airways and is often seen in patients with cystic fibrosis. Currently, there is no …

Mycobacteria–host interactions in human bronchiolar airway organoids

N Iakobachvili, SA Leon‐Icaza, K Knoops… - Molecular …, 2022 - Wiley Online Library
Respiratory infections remain a major global health concern. Tuberculosis is one of the top
10 causes of death worldwide, while infections with Non‐Tuberculous Mycobacteria are …

Preclinical murine models to study lung infection with Mycobacterium abscessus complex

F Nicola, DM Cirillo, NI Lorè - Tuberculosis, 2023 - Elsevier
Mycobacterium abscessus is a non-tuberculous mycobacterium (NTM) able to cause
invasive pulmonary infections, named NTM pulmonary disease. The therapeutic approaches …

Subunit vaccine protects against a clinical isolate of Mycobacterium avium in wild type and immunocompromised mouse models

SE Larsen, VA Reese, T Pecor, BJ Berube… - Scientific reports, 2021 - nature.com
The nontuberculous mycobacteria (NTM) Mycobacterium avium is a clinically significant
pathogen that can cause a wide range of maladies, including tuberculosis-like pulmonary …

Autophagy and host defense in nontuberculous mycobacterial infection

P Silwal, IS Kim, EK Jo - Frontiers in immunology, 2021 - frontiersin.org
Autophagy is critically involved in host defense pathways through targeting and elimination
of numerous pathogens via autophagic machinery. Nontuberculous mycobacteria (NTMs) …

Whole genome sequencing and prediction of antimicrobial susceptibilities in non-tuberculous mycobacteria

P Solanki, M Lipman, TD McHugh, G Satta - Frontiers in Microbiology, 2022 - frontiersin.org
Non-tuberculous mycobacteria (NTM) are opportunistic pathogens commonly causing
chronic, pulmonary disease which is notoriously hard to treat. Current treatment for NTM …

Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus

JM Belardinelli, D Verma, W Li, C Avanzi… - Science translational …, 2022 - science.org
A search for alternative Mycobacterium abscessus treatments led to our interest in the two-
component regulator DosRS, which, in Mycobacterium tuberculosis, is required for the …

Weighted gene co-expression network analysis identifies key modules and hub genes associated with mycobacterial infection of human macrophages

L Lu, RL Wei, S Bhakta, SJ Waddell, E Boix - Antibiotics, 2021 - mdpi.com
Tuberculosis (TB) is still a leading cause of death worldwide. Treatments remain
unsatisfactory due to an incomplete understanding of the underlying host–pathogen …

Probing Dermal Immunity to Mycobacteria through a Controlled Human Infection Model

EC Church, E Bishop, A Fiore-Gartland, KKQ Yu… - …, 2024 - journals.aai.org
Cutaneous mycobacterial infections cause substantial morbidity and are challenging to
diagnose and treat. An improved understanding of the dermal immune response to …