Stress has been consistently linked to negative impacts on physical and mental health. More
specifically, patients with chronic pain experience stress intolerance, which is an …

The US is grappling with an opioid epidemic, with millions of adults on long-term opioid
therapy (LTOT). Although patients often report pain relief and improved daily function with …

Background Approximately 2.7 million individuals in the United States had an opioid use
disorder (OUD) in 2020. Chronic pain may exacerbate opioid withdrawal severity, yet most …

The COVID-19 pandemic continues to have profound health, social, psychological, and
economic ramifications. Infection by COVID-19 has been of concern in people who use …

The control of neuropathic pain is a leading challenge in modern medicine. Traditional
medicine has, for a long time, used natural compounds such as nutraceuticals for this …

Traumatic peripheral neuropathic pain is a complex syndrome caused by a primary lesion or
dysfunction of the peripheral nervous system. Secondary to the lesion, resident or infiltrating …

Morphine, one of the most efficacious analgesics, is effective in severe pain, especially in
patients with concomitant painful cancers. The clinical use of morphine may be …

The devastating complications of coronavirus disease 2019 (COVID-19) result from an
individual's dysfunctional immune response following the initial severe acute respiratory …

The evaluation of chronic pain is challenging because of the lack of specific biomarkers. We
identified the Mu opioid receptor-positive (Mu+) B cell percentage of expression, named Mu …

In terms of pharmaceutical grouping, opioids are natural and synthetic substances derived
and simulated from opium [1, 2] which can activate the neurological system by a connection …