Integrated molecular and immunological features of human T-lymphotropic virus type 1 infection and disease progression to adult T-cell leukaemia or lymphoma

JS O'Donnell, SK Hunt, KJ Chappell - The Lancet Haematology, 2023 - thelancet.com
The human T-lymphotropic virus type 1 (HTLV-1) retrovirus infects 10–20 million people
globally, with endemic regions in southwestern Japan, the Caribbean basin, Africa, and …

Imaging spectrum of HTLV-1–related neurologic disease: a pooled series and review

L Dixon, C McNamara, D Dhasmana… - Neurology: Clinical …, 2023 - AAN Enterprises
Purpose of Review Human T-cell lymphotropic virus type 1 (HTLV-1)–associated
myelopathy (HAM) is a well-recognized neurologic complication of HTLV-1. Beyond HAM …

Long-term safety and efficacy of mogamulizumab (anti-CCR4) for treating virus-associated myelopathy

T Sato, J Yamauchi, N Yagishita, N Araya, N Takao… - Brain, 2023 - academic.oup.com
Some carriers of human T-cell leukaemia virus type 1 (HTLV-1), a retrovirus that primarily
infects CD4+ T cells and causes lifelong infection, develop HTLV-1-associated …

Infectious myelopathies

AM Fletcher, S Bhattacharyya - CONTINUUM: Lifelong Learning in …, 2024 - journals.lww.com
Objective Infectious myelopathy of any stage and etiology carries the potential for significant
morbidity and mortality. This article details the clinical presentation, risk factors, and key …

[HTML][HTML] EZH1/2 dual inhibitors suppress HTLV-1-infected cell proliferation and hyperimmune response in HTLV-1-associated myelopathy

A Koseki, N Araya, M Yamagishi, J Yamauchi… - Frontiers in …, 2023 - frontiersin.org
Background Human T-cell leukemia virus type 1 (HTLV-1) causes HTLV-1-associated
myelopathy (HAM), adult T-cell leukemia/lymphoma (ATL), HTLV-1-associated uveitis, and …

[HTML][HTML] Transient viral activation in human T cell leukemia virus type 1-infected macaques treated with Pomalidomide

A Gutowska, K McKinnon, S Sarkis, MN Doster… - Frontiers in …, 2022 - frontiersin.org
(CTL) and natural killer (NK) cells, suggesting the virus has developed effective mechanisms
to counteract host immune surveillance. We recently showed that in vitro treatment of HTLV …

Advances in the treatment of human T-cell lymphotropic virus type-I associated myelopathy

B Mashkani, M Jalili Nik, SA Rezaee… - Expert Review of …, 2023 - Taylor & Francis
ABSTRACT Introduction Nearly 2–3% of those 10 to 20 million individuals infected with the
Human T-cell lymphotropic virus type-1 (HTLV-1); are predisposed to developing HTLV-1 …

[HTML][HTML] Use of Oral Corticosteroids to Treat HTLV-1-Associated Myelopathy (HAM) in São Paulo, Brazil

FE Dahy, T Assone, RMN Marcusso… - Microbiology …, 2023 - mdpi.com
Simple Summary Our findings provide observational evidence supporting oral
corticosteroids therapy as maintenance therapy for HTLV-1-associated myelopathy (HAM) …

HTLV-1-associated myelopathy in Spain

C de-Mendoza, L Pérez, A Rando, G Reina… - Journal of Clinical …, 2023 - Elsevier
Background HTLV-1 infection is a neglected disease. Over 10 million people are infected
worldwide, with hot spots of high endemicity across all continents. Roughly 5% of HTLV-1 …

[HTML][HTML] New Perspectives about Drug Candidates Targeting HTLV-1 and Related Diseases

MCM Silva, RSB Pereira, ACA Araujo, EGS Filho… - Pharmaceuticals, 2023 - mdpi.com
Among the human T-lymphotropic virus (HTLV) types, HTLV-1 is the most prevalent, and it
has been linked to a spectrum of diseases, including HAM/TSP, ATLL, and hyperinfection …