[HTML][HTML] Redox regulation of FoxO transcription factors

LO Klotz, C Sánchez-Ramos, I Prieto-Arroyo… - Redox biology, 2015 - Elsevier
Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …

Global signatures of protein and mRNA expression levels

R de Sousa Abreu, LO Penalva, EM Marcotte… - Molecular …, 2009 - pubs.rsc.org
Cellular states are determined by differential expression of the cell's proteins. The
relationship between protein and mRNA expression levels informs about the combined …

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

K Abdelmohsen, AC Panda, R Munk… - RNA biology, 2017 - Taylor & Francis
HuR influences gene expression programs and hence cellular phenotypes by binding to
hundreds of coding and noncoding linear RNAs. However, whether HuR binds to circular …

CircInteractome: a web tool for exploring circular RNAs and their interacting proteins and microRNAs

DB Dudekula, AC Panda, I Grammatikakis, S De… - RNA biology, 2016 - Taylor & Francis
Circular RNAs (circRNAs) are widely expressed in animal cells, but their biogenesis and
functions are poorly understood. CircRNAs have been shown to act as sponges for miRNAs …

AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway

T Chen, X Dai, J Dai, C Ding, Z Zhang, Z Lin, J Hu… - Cell Death & …, 2020 - nature.com
Hepatocellular carcinoma (HCC) is a major leading cause of cancer-related death
worldwide. Alpha fetoprotein (AFP) is reactivated in a majority of hepatocellular carcinoma …

[HTML][HTML] Circular RNAs as potential biomarkers for cancer diagnosis and therapy

F Wang, AJ Nazarali, S Ji - American journal of cancer research, 2016 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs) are a naturally occurring type of universal and diverse
endogenous noncoding RNAs which unlike linear RNAs, have covalently linked ends. They …

Posttranslational control of HuR function

I Grammatikakis, K Abdelmohsen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …

HuR recruits let-7/RISC to repress c-Myc expression

HH Kim, Y Kuwano, S Srikantan, EK Lee… - Genes & …, 2009 - genesdev.cshlp.org
RNA-binding proteins (RBPs) and microRNAs (miRNAs) are potent post-transcriptional
regulators of gene expression. Here, we show that the RBP HuR reduced c-Myc expression …

[HTML][HTML] HuR function in disease

S Srikantan, M Gorospe - Frontiers in bioscience (Landmark edition …, 2012 - ncbi.nlm.nih.gov
The cytoplasmic events that control mammalian gene expression, primarily mRNA stability
and translation, potently influence the cellular response to internal and external signals. The …

TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1

KK McDonald, A Aulas… - Human molecular …, 2011 - academic.oup.com
TAR deoxyribonucleic acid-binding protein 43 (TDP-43) is a multifunctional protein with
roles in transcription, pre-messenger ribonucleic acid (mRNA) splicing, mRNA stability and …