Non-targeted effects (NTE) have been generally regarded as a low-dose ionizing radiation
(IR) phenomenon. Recently, regarding long distant abscopal effects have also been …

Sepsis is a manifestation of the immune and inflammatory response to infection, which may
lead to multi‑organ failure. Health care advances have improved outcomes in critical illness …

Background ATM is a multifunctional serine/threonine kinase that in addition to its well-
established role in DNA repair mechanisms is involved in a number of signaling pathways …

The autosomal recessive disorder Ataxia-Telangiectasia is caused by a dysfunction of the
stress response protein, ATM. In the nucleus of proliferating cells, ATM senses DNA double …

Objectives: Identify the abnormal ATM gene in the etiology of ataxia telangiectasia. Outline
the pathophysiology of ataxia telangiectasia. Describe the use of genetic testing to diagnose …

Ataxia Telangiectasia (AT) is an inherited autosomal recessive disorder characterized by
cerebellar neurodegeneration, radiosensitivity, immunodeficiency and a high incidence of …

Ataxia-telangiectasia (AT) is a severe syndromic neurodegenerative inborn error of immunity
characterized by DNA reparation defect, chromosomal instability, and hypersensitivity to …

Cerebellar ataxia is often the first and irreversible outcome in the disease of ataxia‐
telangiectasia (A‐T), as a consequence of selective cerebellar Purkinje neuronal …