The amyloid cascade is the most frequently accepted hypothesis of Alzheimer's Disease
(AD). According to this hypothesis, the formation of plaques precedes the appearance of …

Abstract The Apolipoprotein E ε4 (ApoE ε4) allele, encoding ApoE4, is the strongest genetic
risk factor for late-onset Alzheimer's disease (LOAD). Emerging epidemiological evidence …

Growing evidence supports the use of plasma levels of tau phosphorylated at threonine 181,
amyloid-β, neurofilament light and glial fibrillary acidic protein as promising biomarkers for …

Plasma Alzheimer's disease-related pathological biomarkers' role in Parkinson's disease
(PD) remains unknown. We aimed to determine whether plasma Alzheimer's disease …

Alzheimer's disease (AD) is an incurable degenerative disease of the central nervous
system and the most common type of dementia in the elderly. Despite years of extensive …

Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve
Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging …

Background White matter hyperintensities, a neuroimaging marker of small-vessel
cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are important dementia risk …

Background: Understanding the neurobiological underpinnings between established
multimodal dementia risk factors and noninvasive blood-based biomarkers may lead to …

Background It is not fully established whether plasma β-amyloid (Aβ) 42/Aβ40 and
phosphorylated Tau181 (p-Tau181) can effectively detect Alzheimer's disease (AD) …

Background Hypertensive patients have a younger trend, and studies on the role of genetic
factors in hypertension susceptibility have been inconsistent. Aldehyde dehydrogenases 2 …