Kidney stone disease is a crystal concretion formed usually within the kidneys. It is an
increasing urological disorder of human health, affecting about 12% of the world population …

Urolithiasis, a complex multifactorial disease, results from interactions between
environmental and genetic factors. Epidemiological studies have shown the association of …

Mitochondrion is a pivotal intracellular organelle that plays crucial roles in regulation of
energy production, oxidative stress, calcium homeostasis, and apoptosis. Kidney stone …

Oxidative stress is a major risk factor for calcium oxalate nephrolithiasis. Reports suggest
that oxidative stress response is induced in animals and humans with kidney stones. Keap1 …

The high recurrence rate of cystine lithiasis observed in cystinuria patients highlights the
need for new therapeutic options to address this chronic disease. There is growing evidence …

Escherichia coli (E. coli) is closely associated with the formation of kidney stones. However,
the role of E. coli in CaOx stone formation is not well understood. We explored whether E …

Background Hyperoxaluria causes crystal deposition in the kidney, which leads to oxidative
stress and to injury and damage of the renal epithelium. Sodium thiosulfate (STS, Na2S2O3) …

Cell injury is a necessary and critical event during CaOx kidney stone formation. Sirt1 exerts
a number of pleiotropic effects, protecting against renal cell injury. This study aims to explore …

Crystal modulators play a significant role in the formation of calcium oxalate stone disease.
When renal cells are subjected to oxalate stress, the loss in cell integrity leads to exposure …

Males develop kidney stones far more frequently than females with a ratio of 2–3: 1,
suggesting that androgen receptor (AR) signaling might play a key role in the development …