R-loops are atypical, three-stranded nucleic acid structures that contain a stretch of RNA:
DNA hybrids and an unpaired, single stranded DNA loop. R-loops are physiological relevant …

Since first being documented in ancient times, the relation of inflammation with injury and
disease has evolved in complexity and causality. Early observations supported a cause …

Inherited bone marrow failure syndromes (IBMFSs) include Fanconi anemia, Diamond–
Blackfan anemia, Shwachman–Diamond syndrome, dyskeratosis congenita, severe …

The tumor suppressor BRCA1 accumulates at sites of DNA damage in a ubiquitin‐
dependent manner. In this work, we revisit the role of RAP80 in promoting BRCA1 …

Fanconi anemia (FA) is a rare inherited disorder that mainly affects the bone marrow. This
condition causes decreased production of all types of blood cells. FA is caused by a …

Although hematopoietic stem cells (HSCs) in the bone marrow are in a state of quiescence,
they harbor the self-renewal capacity and the pluripotency to differentiate into mature blood …

Fanconi anemia (FA) is a rare genetic disorder characterized by bone marrow failure and
aplastic anemia. So far, 23 genes are involved in this pathology, and their mutations lead to …

Leukaemia is caused by the clonal evolution of a cell that accumulates mutations/genomic
rearrangements, allowing unrestrained cell growth. However, recent identification of …

In brief Fanconi anemia results in subfertility and germ cell deficiency in women. We present
histological and RNA-seq analysis of Fance-deficient primordial germ cells to explore the …

With the continuous development of nuclear technology, the radiation exposure caused by
radiation therapy is a serious health hazard. It is of great significance to further develop …