Vascularization is the key challenge in tissue engineering

EC Novosel, C Kleinhans, PJ Kluger - Advanced drug delivery reviews, 2011 - Elsevier
The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel
system—the vascularization. In vivo almost all tissues are supplied by these endothelial cell …

Strategies for directing the structure and function of three-dimensional collagen biomaterials across length scales

BD Walters, JP Stegemann - Acta biomaterialia, 2014 - Elsevier
Collagen type I is a widely used natural biomaterial that has found utility in a variety of
biological and medical applications. Its well-characterized structure and role as an …

Hydrogel based injectable scaffolds for cardiac tissue regeneration

J Radhakrishnan, UM Krishnan, S Sethuraman - Biotechnology advances, 2014 - Elsevier
Tissue engineering promises to be an effective strategy that can overcome the lacuna
existing in the current pharmacological and interventional therapies and heart …

Bottom-up tissue engineering

DL Elbert - Current opinion in biotechnology, 2011 - Elsevier
Recapitulating the elegant structures formed during development is an extreme synthetic
and biological challenge. Great progress has been made in developing materials to support …

Modular tissue assembly strategies for biofabrication of engineered cartilage

BS Schon, GJ Hooper, TBF Woodfield - Annals of biomedical engineering, 2017 - Springer
This review describes the prospects of applying modular assembly techniques and
strategies for fabrication of advanced tissue engineered cartilage constructs. Articular …

Nano-porous anodic alumina: Fundamentals and applications in tissue engineering

E Davoodi, M Zhianmanesh, H Montazerian… - Journal of Materials …, 2020 - Springer
Recently, nanomaterials have been widely utilized in tissue engineering applications due to
their unique properties such as the high surface to volume ratio and diversity of morphology …

[HTML][HTML] A glycosaminoglycan based, modular tissue scaffold system for rapid assembly of perfusable, high cell density, engineered tissues

R Tiruvannamalai-Annamalai, DR Armant… - PloS one, 2014 - journals.plos.org
The limited ability to vascularize and perfuse thick, cell-laden tissue constructs has hindered
efforts to engineer complex tissues and organs, including liver, heart and kidney. The …

Materials science and tissue engineering: repairing the heart

M Radisic, KL Christman - Mayo clinic proceedings, 2013 - Elsevier
Heart failure after a myocardial infarction continues to be a leading killer in the Western
world. Currently, there are no therapies that effectively prevent or reverse the cardiac …

Cell therapy, 3D culture systems and tissue engineering for cardiac regeneration

MY Emmert, RW Hitchcock, SP Hoerstrup - Advanced drug delivery reviews, 2014 - Elsevier
Abstract Ischemic Heart Disease (IHD) still represents the “Number One Killer” worldwide
accounting for the death of numerous patients. However the capacity for self-regeneration of …

The expanding world of tissue engineering: the building blocks and new applications of tissue engineered constructs

P Zorlutuna, NE Vrana… - IEEE reviews in …, 2012 - ieeexplore.ieee.org
The field of tissue engineering has been growing in the recent years as more products have
made it to the market and as new uses for the engineered tissues have emerged, motivating …