[HTML][HTML] Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes
IA McNeish, SJ Bell, NR Lemoine - Gene therapy, 2004 - nature.com
Targeting tumour suppressor gene pathways is an attractive therapeutic strategy in cancer.
Since the first clinical trial took place in 1996, at least 20 other trials have investigated the …
Since the first clinical trial took place in 1996, at least 20 other trials have investigated the …
[HTML][HTML] A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
The tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore
reasonable to assume that naturally occurring polymorphic genetic variants in the p53 stress …
reasonable to assume that naturally occurring polymorphic genetic variants in the p53 stress …
DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer
RA Gjerset - Journal of molecular histology, 2006 - Springer
Abstract The p53/p14ARF/mdm2 stress response pathway plays a central role in mediating
cellular responses to oncogene activation, genome instability, and therapy-induced DNA …
cellular responses to oncogene activation, genome instability, and therapy-induced DNA …
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
MDM2 is a RING domain ubiquitin E3 ligase and a major regulator of the p53 tumor
suppressor. MDM2 binds to p53, inactivates p53 transcription function, inhibits p53 …
suppressor. MDM2 binds to p53, inactivates p53 transcription function, inhibits p53 …
MDM2 promotes ubiquitination and degradation of MDMX
Y Pan, J Chen - Molecular and cellular biology, 2003 - Taylor & Francis
The p53 tumor suppressor is regulated by MDM2-mediated ubiquitination and degradation.
Mitogenic signals activate p53 by induction of ARF expression, which inhibits p53 …
Mitogenic signals activate p53 by induction of ARF expression, which inhibits p53 …
Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53
S Licciulli, JL Avila, L Hanlon, S Troutman, M Cesaroni… - Cancer research, 2013 - AACR
The Notch pathway has been implicated in a number of malignancies with different roles that
are cell-and tissue-type dependent. Notch1 is a putative oncogene in non–small cell lung …
are cell-and tissue-type dependent. Notch1 is a putative oncogene in non–small cell lung …
Low-dose radiation hypersensitivity is associated with p53-dependent apoptosis
L Enns, KT Bogen, J Wizniak, AD Murtha… - Molecular Cancer …, 2004 - AACR
Exposure to environmental radiation and the application of new clinical modalities, such as
radioimmunotherapy, have heightened the need to understand cellular responses to low …
radioimmunotherapy, have heightened the need to understand cellular responses to low …
[HTML][HTML] Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling
Abstract Mitochondrial malic enzyme 2 (ME2) catalyzes the oxidative decarboxylation of
malate to yield CO2 and pyruvate, with concomitant reduction of dinucleotide cofactor NAD+ …
malate to yield CO2 and pyruvate, with concomitant reduction of dinucleotide cofactor NAD+ …
Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity
T Teng, CA Mercer, P Hexley, G Thomas… - … and cellular biology, 2013 - Taylor & Francis
Humans have evolved elaborate mechanisms to activate p53 in response to insults that lead
to cancer, including the binding and inhibition of Hdm2 by the 60S ribosomal proteins (RPs) …
to cancer, including the binding and inhibition of Hdm2 by the 60S ribosomal proteins (RPs) …
miR-34c may protect lung cancer cells from paclitaxel-induced apoptosis
S Catuogno, L Cerchia, G Romano, P Pognonec… - Oncogene, 2013 - nature.com
MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that negatively regulate
the expression of their target genes. They are involved in many biological processes …
the expression of their target genes. They are involved in many biological processes …