[HTML][HTML] Polycomb directed cell fate decisions in development and cancer
B German, L Ellis - Epigenomes, 2022 - mdpi.com
The polycomb group (PcG) proteins are a subset of transcription regulators highly conserved
throughout evolution. Their principal role is to epigenetically modify chromatin landscapes …
throughout evolution. Their principal role is to epigenetically modify chromatin landscapes …
EZH2-Myc Hallmark in Oncovirus/Cytomegalovirus Infections and Cytomegalovirus' Resemblance to Oncoviruses
R El Baba, G Herbein - Cells, 2024 - mdpi.com
Approximately 15–20% of global cancer cases are attributed to virus infections. Oncoviruses
employ various molecular strategies to enhance replication and persistence. Human …
employ various molecular strategies to enhance replication and persistence. Human …
Deciphering the role of immune cell composition in epigenetic age acceleration: Insights from cell‐type deconvolution applied to human blood epigenetic clocks
Aging is a significant risk factor for various human disorders, and DNA methylation clocks
have emerged as powerful tools for estimating biological age and predicting health‐related …
have emerged as powerful tools for estimating biological age and predicting health‐related …
Depletion of enhancer zeste homolog 2 (EZH2) directs transcription factors associated with T cell differentiation through epigenetic regulation of Yin Yang 1 (YY1) in …
N Chandnani, VS Choudhari, R Talukdar, S Rakshit… - Medical Oncology, 2023 - Springer
Abstract Non-Small Cell Lung Cancer (NSCLC) is the leading cause of death in all countries
alike. In the current study, we have found out that Histone H3Lys4trimethylation is abnormal …
alike. In the current study, we have found out that Histone H3Lys4trimethylation is abnormal …
Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma
N Qiang, J Ao, M Nakamura, T Chiba… - International …, 2023 - Elsevier
Enhancer of zeste homolog 2 (EZH2), a core component of polycomb repressive component
2 is overexpressed in a variety of cancers and recognized as a therapeutic target molecule …
2 is overexpressed in a variety of cancers and recognized as a therapeutic target molecule …
EZH2 Inhibition Enhances PD‐L1 Protein Stability Through USP22‐Mediated Deubiquitination in Colorectal Cancer
J Huang, Q Yin, Y Wang, X Zhou, Y Guo… - Advanced …, 2024 - Wiley Online Library
The regulation of PD‐L1 is the key question, which largely determines the outcome of the
immune checkpoint inhibitors (ICIs) based therapy. However, besides the transcription level …
immune checkpoint inhibitors (ICIs) based therapy. However, besides the transcription level …
[HTML][HTML] PROTAC EZH2 degrader-1 overcomes the resistance of podophyllotoxin derivatives in refractory small cell lung cancer with leptomeningeal metastasis
M Shi, X Ding, L Tang, W Cao, B Su, J Zhang - BMC cancer, 2024 - Springer
Background Leptomeningeal metastasis (LM) of small cell lung cancer (SCLC) is a highly
detrimental occurrence associated with severe neurological disorders, lacking effective …
detrimental occurrence associated with severe neurological disorders, lacking effective …
A comprehensive insight into the contribution of epigenetics in male infertility; focusing on immunological modifications
CY Hsu, SA Jasim, H Pallathadka, A Kumar… - Journal of Reproductive …, 2024 - Elsevier
Numerous recent studies have examined the impact epigenetics—including DNA
methylation—has on spermatogenesis and male infertility. Differential methylation of several …
methylation—has on spermatogenesis and male infertility. Differential methylation of several …
[HTML][HTML] EZH2: The roles in targeted therapy and mechanisms of resistance in breast cancer
Y Chen, H Zhu, Y Luo, S Tong, Y Liu - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Drug resistance presents a formidable challenge in the realm of breast cancer therapy.
Accumulating evidence suggests that enhancer of zeste homolog 2 (EZH2), a component of …
Accumulating evidence suggests that enhancer of zeste homolog 2 (EZH2), a component of …
[HTML][HTML] Epigenetic Modulations in Triple-Negative Breast Cancer: Therapeutic Implications for Tumor Microenvironment
L Zhou, CW Yu - Pharmacological Research, 2024 - Elsevier
Triple-negative breast cancer (TNBC) is an aggressive subtype lacking estrogen receptors,
progesterone receptors and lacks HER2 overexpression. This absence of critical molecular …
progesterone receptors and lacks HER2 overexpression. This absence of critical molecular …