Solubility is an essential criterion for attaining desired concentration of the drug within the
systemic circulation to ensure intended pharmacological action. The main setback for the …

Oral anticancer therapy faces several drawbacks: low aqueous solubility, poor and irregular
absorption from gastrointestinal sites, high first-pass metabolism, food-influenced …

The aim of the present investigation was to enhance the solubility, dissolution, and oral
bioavailability of praziquantel (PZQ), a poorly water-soluble BCS II drug (Biopharmaceutical …

This study aimed to develop valsartan (VAL)-loaded mixed micelles and investigate their
cardioprotective potential and molecular mechanisms through Mhrt/Nrf2 and Trx1 pathways …

Valsartan (VST) is a poorly soluble antihypertensive drug characterized by its limited
dissolution rate and low bioavailability. This study aims to improve VST solubility and …

Background: The oral route is a highly recommended route for the delivery of a drug. But
most lipophilic drugs are difficult to deliver via this route due to their low aqueous solubility …

Many of the recently approved drug molecules that are therapeutically successful are found
to be incompatible for the development of a novel delivery system and to take part in various …

Self-nanoemulsifying drug delivery system (SNEDDS) has emerged as a promising platform
to improve oral absorption of drugs with poor solubility and low permeability. However, large …

A novel solid self-dispersing micelle (S-SDM) was developed to enhance the oral
bioavailability of valsartan (VST) and to reduce the total mass of solidified supersaturable …

摘要目的: 探讨原发性肾病综合征(NS) 患儿在醋酸泼尼松片治疗的基础上联合缬沙坦胶囊治疗
的临床疗效及对肾功能和炎性因子的影响. 方法: 选取2017 年2 月~ 2019 年4 …