[HTML][HTML] Targeting STAT3 signaling pathway in colorectal cancer
Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor that
has been firmly associated with colorectal cancer (CRC) initiation and development. STAT3 …
has been firmly associated with colorectal cancer (CRC) initiation and development. STAT3 …
Crosstalk between long non-coding RNAs and p53 signaling pathway in colorectal cancer: A review study
MM Khanifar, Z Zafari, M Sheykhhasan - Pathology-Research and Practice, 2023 - Elsevier
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and the third
leading cause of cancer-related fatalities. Long non-coding RNAs (lncRNAs) are key …
leading cause of cancer-related fatalities. Long non-coding RNAs (lncRNAs) are key …
Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis
X Wu, H Yan, M Qiu, X Qu, J Wang, S Xu, Y Zheng… - Elife, 2023 - elifesciences.org
Colorectal cancer (CRC) remains a challenging and deadly disease with high tumor
microenvironment (TME) heterogeneity. Using an integrative multi-omics analysis and …
microenvironment (TME) heterogeneity. Using an integrative multi-omics analysis and …
[HTML][HTML] Molecular characteristics, oncogenic roles, and relevant immune and pharmacogenomic features of EVA1B in colorectal cancer
B Ma, K Wang, Y Liang, Q Meng, Y Li - Frontiers in Immunology, 2022 - frontiersin.org
Objective EVA1B, a protein coding gene, is a critical paralog of EVA1A gene. Herein, our
study was conducted to investigate the role of EVA1B in colorectal cancer (CRC) …
study was conducted to investigate the role of EVA1B in colorectal cancer (CRC) …
NeuroD1 promotes tumor cell proliferation and tumorigenesis by directly activating the pentose phosphate pathway in colorectal carcinoma
Z Li, Y He, Y Li, J Li, H Zhao, G Song, M Miyagishi… - Oncogene, 2021 - nature.com
Tumor metabolic reprogramming ensures that cancerous cells obtain sufficient building
blocks, energy, and antioxidants to sustain rapid growth and for coping with oxidative stress …
blocks, energy, and antioxidants to sustain rapid growth and for coping with oxidative stress …
New benzimidazole based hybrids: synthesis, molecular modeling study and anticancer evaluation as TopoII inhibitors
NA Nawareg, AS Mostafa, SM El-Messery… - Bioorganic …, 2022 - Elsevier
Three series of new benzimidazole hybrids were designed and synthesized as promising
human TopoII inhibitors. They were characterized by different spectroscopic techniques (1 …
human TopoII inhibitors. They were characterized by different spectroscopic techniques (1 …
[HTML][HTML] HOXB9 Overexpression Promotes Colorectal Cancer Progression and Is Associated with Worse Survival in Liver Resection Patients for Colorectal Liver …
E Martinou, C Moller-Levet, D Karamanis… - International journal of …, 2022 - mdpi.com
As is known, HOXB9 is an important factor affecting disease progression and overall survival
(OS) in cancer. However, its role in colorectal cancer (CRC) remains unclear. We aimed to …
(OS) in cancer. However, its role in colorectal cancer (CRC) remains unclear. We aimed to …
[HTML][HTML] A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
J Qu, M Luo, J Zhang, F Han, N Hou, R Pan… - Cancer Cell …, 2021 - Springer
Sestrin 2, a highly conserved stress-induced protein, participates in the pathological
processes of metabolic and age-related diseases. This p53-inducible protein also regulates …
processes of metabolic and age-related diseases. This p53-inducible protein also regulates …
Zinc finger protein 280C contributes to colorectal tumorigenesis by maintaining epigenetic repression at H3K27me3-marked loci
Y Ying, M Wang, Y Chen, M Li, C Ma… - Proceedings of the …, 2022 - National Acad Sciences
Dysregulated epigenetic and transcriptional programming due to abnormalities of
transcription factors (TFs) contributes to and sustains the oncogenicity of cancer cells. Here …
transcription factors (TFs) contributes to and sustains the oncogenicity of cancer cells. Here …
Genistin modulates high-mobility group box protein 1 (HMGB1) and nuclear factor kappa-B (NF-κB) in Ehrlich-ascites-carcinoma-bearing mice
Cancer is the world's second-largest cause of death. Although there are numerous cancer
treatment options, they are typically uncomfortable owing to side effects and ineffectual due …
treatment options, they are typically uncomfortable owing to side effects and ineffectual due …